{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:03:14Z","timestamp":1777892594471,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Vitamin B12 deficiency and folate deficiency are common causes of macrocytic anaemia and both are important for many cellular processes. These deficiencies could be due to inadequate dietary intake, impaired absorption or drug ingestion. We present a case of a 47-year-old male with a history of diffuse large B-cell lymphoma (DLBCL) who was admitted for fatigue, persistent frontal headache and left upper-quadrant abdominal pain. Further investigation showed that he had pancytopenia with microangiopathic haemolytic anaemia (MAHA) and intracranial bleeding (ICB). Serum vitamin B12 and folate were later found to be low and a diagnosis of combined vitamin B12 and folate deficiency mimicking thrombotic thrombocytopenic purpura (TTP) was made. The patient responded well to vitamin B12 and folate replacement.<\/jats:p>","DOI":"10.4997\/jrcpe.2020.213","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T10:27:56Z","timestamp":1592476076000},"page":"144-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Microangiopathic Haemolytic Anaemia and Thrombocytopenia Due to Combined Vitamin B12 and Folate Deficiency Masquerading as Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1177","volume":"50","author":[{"given":"Kee Tat","family":"Lee","sequence":"first","affiliation":[{"name":"Clinical Specialist, Department of Medicine, Hospital Pulau Pinang, Pulau Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Soon","family":"Teoh","sequence":"additional","affiliation":[{"name":"Consultant Hematologists, Hematology unit, Department of Medicine, Hospital Pulau Pinang, Pulau Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng Keat","family":"Chew","sequence":"additional","affiliation":[{"name":"Consultant Hematologists, Hematology unit, Department of Medicine, Hospital Pulau Pinang, Pulau Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Sim","family":"Goh","sequence":"additional","affiliation":[{"name":"Consultant Hematologists, Hematology unit, Department of Medicine, Hospital Pulau Pinang, Pulau Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"bibr1-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1201\/9781420071252-c15"},{"key":"bibr2-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0106-5"},{"key":"bibr3-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000115161.10646.67"},{"key":"bibr4-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000169934.96354.3a"},{"key":"bibr5-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043442"},{"key":"bibr6-jrcpe.2020.213","volume-title":"Clinical haematology atlas","author":"Rodak B","year":"2013"},{"key":"bibr7-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00755.x"},{"key":"bibr8-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013367"},{"key":"bibr9-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06880.x"},{"key":"bibr10-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2015.12.004"},{"key":"bibr11-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.9.1349"},{"key":"bibr12-jrcpe.2020.213","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090202"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:32:53Z","timestamp":1777617173000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2020.213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.4997\/jrcpe.2020.213"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2020.213","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}