{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:03:15Z","timestamp":1777892595568,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>We report the case of a 67-year-old male who presented with a six-week history of progressive unsteadiness, cognitive impairment and weight loss, in the context of a recent bereavement. Magnetic resonance imaging (MRI) performed several weeks earlier excluded acute stroke.<\/jats:p>\n                  <jats:p>Examination revealed gross bilateral ataxia, bradyphrenia and physical manifestations of depression. Collateral history suggested rapidly progressing symptoms over three months. Repeat MRI head showed features suggestive of Creutzfeldt-Jakob disease (CJD) including T2 hyperintensities in the basal ganglia. Cerebrospinal fluid (CSF) samples were positive for 14-3-3 protein, S100b and real-time quaking-induced conversion (RT-QuIC) proteins confirming the diagnosis of sporadic CJD (sCJD).<\/jats:p>","DOI":"10.4997\/jrcpe.2020.313","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T05:53:01Z","timestamp":1599803581000},"page":"281-283","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Progressive Ataxia and Cognitive Decline in a 67-Year-Old Male: A Diagnostic Challenge"],"prefix":"10.1177","volume":"50","author":[{"given":"Dina","family":"Osman","sequence":"first","affiliation":[{"name":"Core Medical Trainee, Cumberland Infirmary of Carlisle, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Weidner","sequence":"additional","affiliation":[{"name":"Specialist Trainee in Gastroenterology and General Internal Medicine, Cumberland Infirmary of Carlisle, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuri","family":"Madhra","sequence":"additional","affiliation":[{"name":"Specialist Trainee in Geriatrics and General Internal Medicine, Cumberland Infirmary of Carlisle, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"bibr1-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.519"},{"key":"bibr2-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2016-001571"},{"key":"bibr3-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-7766.2002.05057.x"},{"key":"bibr4-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812313392707"},{"key":"bibr5-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1061-0"},{"key":"bibr6-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70192-7"},{"key":"bibr7-jrcpe.2020.313","unstructured":"The University of Edinburgh. National CJD Research and Surveillance Unit. Clinical features of human prion disease. https:\/\/www.cjd.ed.ac.uk\/sites\/default\/files\/clinfeat.pdf (accessed 1\/12\/19)."},{"key":"bibr8-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2018-001935"},{"key":"bibr9-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0507-x"},{"key":"bibr10-jrcpe.2020.313","unstructured":"The University of Edinburgh. National CJD Research and Surveillance Unit. Protocol for surveillance of CJD in the UK. 2017, http:\/\/www.cjd.ed.ac.uk\/sites\/default\/files\/NCJDRSU%20surveillance%20protocol-january%202017.pdf (accessed 1\/12\/19)."},{"key":"bibr11-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-153"},{"key":"bibr12-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000230159.67128.00"},{"key":"bibr13-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200009)48:3<395::AID-ANA18>3.0.CO;2-A"},{"key":"bibr14-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430109"},{"key":"bibr15-jrcpe.2020.313","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826d5fc3"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:33:21Z","timestamp":1777617201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2020.313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.4997\/jrcpe.2020.313"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2020.313","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}