{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:03:29Z","timestamp":1777892609226,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>A 16-year-old male with Becker muscular dystrophy was admitted to hospital with a significant liver injury due to paracetamol. The dosage of paracetamol ingested was within current guidance yet there was sudden derangement of liver function. The patient was treated with five days of N-acetyl cysteine to which he responded, with his alanine aminotransferase improving from 5,599 to 652 and international normalised ratio from 5.0 to 0.9. He had risk factors for paracetamol toxicity as he was malnourished and had muscular dystrophy. The purpose of this case report is to highlight that despite prescribing approved dosages of paracetamol some patients may have toxicity due to altered body composition and pharmacokinetics.<\/jats:p>","DOI":"10.4997\/jrcpe.2020.413","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T07:50:47Z","timestamp":1610351447000},"page":"411-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Normal Dose Paracetamol in Muscular Dystrophy Patients \u2013 is it Normal?"],"prefix":"10.1177","volume":"50","author":[{"given":"James Liu","family":"Yin","sequence":"first","affiliation":[{"name":"Gastroenterology Specialist Registrar, Croydon University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuok Shern","family":"Teo","sequence":"additional","affiliation":[{"name":"Lead Pharmacist, Croydon University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinu","family":"Philipose","sequence":"additional","affiliation":[{"name":"Consultant Gastroenterologist and Hepatologist, Croydon University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"bibr1-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206cc8f"},{"key":"bibr2-jrcpe.2020.413","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2044.2007.05340.x","volume":"63","author":"Pearce B","year":"2008","journal-title":"Anaesthesia"},{"key":"bibr3-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1999.tb123758.x"},{"key":"bibr4-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6764"},{"key":"bibr5-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2015.04.006"},{"key":"bibr6-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199701000-00016"},{"key":"bibr7-jrcpe.2020.413","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx173"},{"key":"bibr8-jrcpe.2020.413","unstructured":"UK National Poisons Information Service, TOXBASE (Nov 2017) https:\/\/www.toxbase.org\/Poisons-Index-A-Z\/P-Products\/Paracetamol\/ Accessed 29 June 2020"},{"key":"bibr9-jrcpe.2020.413","unstructured":"British National formulary (Online). London: BMJ Group and Pharamaceutical Press; http:\/\/www.medicinescomplete.comAccessed29June2020"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2020.413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:33:44Z","timestamp":1777617224000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2020.413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.4997\/jrcpe.2020.413"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2020.413","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}