{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:03:55Z","timestamp":1777892635805,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Eradication therapy in Plasmodium vivax in variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency individuals remains a clinical challenge. We present a case of primaquine-induced methaemoglobinaemia and haemolytic anaemia in a patient with falsely normal qualitative G6PD result during initial presentation, which was complicated with clinical sequelae of thrombosis. Further investigations showed moderate degree of G6PD deficiency. Our patient responded well to vitamin C and a modified weekly regimen of primaquine with no evidence of malaria relapse.<\/jats:p>","DOI":"10.4997\/jrcpe.2021.210","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T13:05:56Z","timestamp":1624107956000},"page":"146-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Mystery of \u2018Saturation Gap\u2019 and Falsely Normal G6Pd: A Case of Primaquine-Induced Haemolysis in\n                    <i>Plasmodium Vivax<\/i>\n                    Malaria Infection"],"prefix":"10.1177","volume":"51","author":[{"given":"Andy Sing Ong","family":"Tang","sequence":"first","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Yin","family":"Soo","sequence":"additional","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siaw Tze","family":"Yeo","sequence":"additional","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor Ainiza","family":"Mansor","sequence":"additional","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee Ping","family":"Chew","sequence":"additional","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hock Hin","family":"Chua","sequence":"additional","affiliation":[{"name":"Physician, Clinical Registrar, Clinical Pharmacist, Department of Internal Medicine, Haematopathologist, Department of Pathology, Consultant Haematologist, Haematology Unit, Infectious Disease Consultant, Infectious Disease Unit, Department of Internal Medicine, Sarawak General Hospital, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"bibr1-jrcpe.2021.210","unstructured":"World Health Organization (WHO). World Malaria Report 2018. Geneva: WHO;2018."},{"key":"bibr2-jrcpe.2021.210","first-page":"601","volume":"67","author":"WHO Working Group","year":"1989","journal-title":"Bull World Health Organ"},{"key":"bibr3-jrcpe.2021.210","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"bibr4-jrcpe.2021.210","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23061"},{"key":"bibr5-jrcpe.2021.210","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9103"},{"key":"bibr6-jrcpe.2021.210","unstructured":"Bain BJ, Bates I, Laffan MA. Dacie and Lewis Practical Haematology 12th ed. 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