{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:04:21Z","timestamp":1777892661016,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Royal College of Physicians of Edinburgh"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Premature ventricular contractions (PVCs) are heart beats initiated in the ventricles instead of in the sinoatrial node. A high burden of PVCs can lead to a cardiomyopathy, characterised by reduced left ventricular (LV) systolic dysfunction. We present a case of PVC-related cardiomyopathy where the 65-year-old male was initially seen by his primary care provider for recent onset chest pain and dizziness. His transthoracic echocardiogram showed mild concentric LV hypertrophy and mildly reduced systolic function (LV ejection fraction 43%). There was also mild right ventricular (RV) systolic dysfunction. He was started on a beta-blocker and an angiotensin-converting enzyme inhibitor. A 24-hour Holter monitor showed a very high burden of PVCs (32% of all beats). He continued to have frequent PVCs and his echocardiogram did not improve. He was eventually referred for a PVC ablation. Following the ablation, a repeat Holter monitor showed a marked reduction in PVC burden (&lt;1% of beats) and his echocardiogram had normalised.<\/jats:p>","DOI":"10.4997\/jrcpe.2021.311","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T12:42:46Z","timestamp":1631450566000},"page":"262-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Premature Ventricular Contractions-Related Cardiomyopathy"],"prefix":"10.1177","volume":"51","author":[{"given":"Enoch","family":"Chung","sequence":"first","affiliation":[{"name":"Medical Student"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Young","sequence":"additional","affiliation":[{"name":"Medical Student, Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Chen","sequence":"additional","affiliation":[{"name":"Physician & Associate Professor, University of Washington Division of Cardiology, Department of Medicine, Harborview Medical Center, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"bibr1-jrcpe.2021.311","unstructured":"Farzam K, Richards JR. Premature ventricular contraction. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2020."},{"key":"bibr2-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2018.23.2"},{"key":"bibr3-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.08.025"},{"key":"bibr4-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63724-5"},{"key":"bibr5-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.963348"},{"key":"bibr6-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00287-7"},{"key":"bibr7-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.08.004"},{"key":"bibr8-jrcpe.2021.311","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.12.018"}],"container-title":["Journal of the Royal College of Physicians of Edinburgh"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2021.311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4997\/jrcpe.2021.311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:35:13Z","timestamp":1777617313000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4997\/jrcpe.2021.311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.4997\/jrcpe.2021.311"],"URL":"https:\/\/doi.org\/10.4997\/jrcpe.2021.311","relation":{},"ISSN":["1478-2715","2042-8189"],"issn-type":[{"value":"1478-2715","type":"print"},{"value":"2042-8189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}