{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:59:15Z","timestamp":1781153955375,"version":"3.54.1"},"reference-count":0,"publisher":"Oman Medical Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oman Med J"],"abstract":"<jats:p>Objectives: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. It is suggested that mechanisms of many diseases involve \u2018sterile inflammation\u2019 triggered by oxidative stress in the absence of infection. Inflammasomes regulate such inflammatory processes. Antioxidants can counter oxidative stress, but their exact relationship with inflammasome activity in MS is unclear. This study aimed to investigate the association between inflammasome markers and antioxidant vitamins D and E in Jordanian patients with MS. Methods: We enrolled 100 patients with MS and 100 healthy controls. Their blood samples were analyzed by enzyme-linked immunosorbent assay (ELISA) for levels of interleukin-18 (IL-18), IL-1 beta (IL-1\u03b2), nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain\u2013containing protein 3 (NLRP3), and vitamins D and E. Results: Patients with MS had significantly higher serum levels of IL-18 (p =0.020), IL-1 \u03b2 (p &lt;0.001), and NLRP3 (p =0.040) compared with the controls. Serum NLRP3 had an inverse correlation with vitamin D (r = -0.20; p =0.020). Moreover, a significant negative correlation existed between IL-1 \u03b2 and vitamin E (r = -0.14; p =0.040). Conclusions: Our findings suggest that inflammasome activation in MS is linked to decreased levels of antioxidant vitamins. Hence, inflammasome marker levels may serve as future potential biomarkers of disease activity and progression in MS.<\/jats:p>","DOI":"10.5001\/omj.2025.94","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:56:43Z","timestamp":1761206203000},"page":"e776-e776","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum Levels of Vitamins D and E with Markers of NLRP3-inflammasome Pathway in Multiple Sclerosis"],"prefix":"10.5001","volume":"40","author":[{"given":"Refat M.","family":"Nimer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moh\u2019d Mohanad","family":"Al-Dabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Alfaqih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wail M.","family":"Annab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras K.","family":"Weshah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2907","published-online":{"date-parts":[[2025,7,31]]},"container-title":["Oman Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:22:39Z","timestamp":1781151759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.omjournal.org\/articleDetails.aspx?coType=1&aId=4145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7,31]]}},"URL":"https:\/\/doi.org\/10.5001\/omj.2025.94","relation":{},"ISSN":["1999-768X","2070-5204"],"issn-type":[{"value":"1999-768X","type":"print"},{"value":"2070-5204","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}