{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:16:54Z","timestamp":1754558214362,"version":"3.40.4"},"reference-count":8,"publisher":"Jaypee Brothers Medical Publishing","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,9,7]]},"abstract":"Introduction: Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease. The spectrum of NAFLD includes simple steatosis, nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. Our study aimed to calculate visceral fat volume at the L3\u2013L4 vertebral level and its association with hepatic fibrosis assessed by transient elastography. Methods: All patients above 18 years undergoing computed tomography (CT) abdomen in the Department of Radiodiagnosis of Medical College Thiruvananthapuram during the study period with NAFLD were included. Transient elastography was done. Patients were categorized to advanced fibrosis (>10 kPa) and without advanced fibrosis (<10 kPa). The area under the receiver operating characteristic (AUROC) curve was plotted. Results: Sixty-four patients comprised 36 males and 28 females. Thirty-one (46%) were having advanced fibrosis (transient elastography>10 kPa) and 34 (54%) patients were without advanced fibrosis. About 0.733 was the AUROC for visceral fat in predicting advanced fibrosis. The cutoff was 167.5cm3 (sensitivity was 77.4% and specificity was 51.5% in predicting advanced fibrosis). Conclusion: About 0.733 was the AUROC for visceral fat in predicting advanced fibrosis. The cutoff was 167.5cm3 (sensitivity was 77.4% and specificity was 51.5% in predicting advanced fibrosis).<\/jats:p>","DOI":"10.5005\/japi-11001-0097","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T08:22:21Z","timestamp":1669018941000},"page":"23-24","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Visceral Fat Volume and Its Correlation with the Severity of Hepatic Fibrosis in Patients with NAFLD"],"prefix":"10.59556","volume":"70","author":[{"given":"Jijo","family":"Varghese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnadas","family":"Devadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathan","family":"Cyriac Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tharun","family":"Tom Oommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Hareendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nibin","family":"Nahaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bony","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"van der Poorten D, Milner K-L, Hui J, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008;48(2):447\u2013459.","DOI":"10.1002\/hep.22350"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Kobayashi J, Tadokoro N, Watanabe M. A novel method of measuring intra-abdominal fat volume using helical computed tomography. Int J Obes Relat Metab Disord 2002;26(3):398\u2013402.","DOI":"10.1038\/sj.ijo.0801921"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Harrison SA, Oliver D, Arnod HL, et al. Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease. Gut 2008;57(10):1441\u20131447.","DOI":"10.1136\/gut.2007.146019"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Shah A, Lydecker A, Murray K, et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. 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Aliment Pharmacol Ther 2015;42(1):106\u2013116.","DOI":"10.1111\/apt.13216"}],"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:56:52Z","timestamp":1745578612000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0097_p23-24.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,1]]},"published-print":{"date-parts":[[2022,9,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0097","relation":{},"ISSN":["0004-5772"],"issn-type":[{"type":"print","value":"0004-5772"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}