{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:04:55Z","timestamp":1745640295907,"version":"3.40.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,10,7]]},"abstract":"<jats:p>Introduction: Barrett\u2019s esophagus (BE) is a complication of gastroesophageal reflux disease (GERD).  It is seen among 15% of GERD patients as per a population-based study by Ronkainen et  al.  Barrett\u2019s has malignant potential and annual progression to carcinoma depends on the presence  or absence of dysplasia. There are various risk factors for the development of BE. We compared  two symptomatic cohorts of GERD patients from the same geographical area who were evaluated  for the presence of Barrett\u2019s and various factors that can contribute to Barrett\u2019s. Materials and methods: Cross-sectional study. Two GERD cohorts, one from Kottayam and the  other from Trivandrum were taken. The presence of Barrett\u2019s and the factors contributing to the  development of Barrett\u2019s were analyzed between the two groups. Since biopsy data of all patients  were not available, endoscopically suspected esophageal metaplasia (ESEM) was taken as Barrett\u2019s. Results: 415 patients were enrolled for the study (203 from Trivandrum and 212 from Kottayam).  192 females (99 from Trivandrum and 93 from Kottayam), and 223 males (104 from Trivandrum and  119 from Kottayam). Barrett\u2019s esophagus and especially long-segment Barrett\u2019s were significantly  more common in Kottayam than Trivandrum (68 vs 22 and 36 vs 9) (p-value &lt;0.001). Among the  factors that were traditionally thought to contribute to the development of Barrett\u2019s esophagus,  age (&gt;50 years) was not statistically significant among the two cohorts (mean age of Trivandrum  was 48 years and Kottayam was 49 years). Duration of GERD symptoms was significantly more  in the Trivandrum cohort compared to Kottayam (p-value &lt;0.001). Hiatus hernia and body mass  index (BMI) were more common in Kottayam. There were no statistically significant differences  in erosive esophagitis and antral gastritis (%age?) between the two cohorts. Conclusion: Both Trivandrum and Kottayam belong to the same geographical area and are  separated by a distance of only 150 km. The Kottayam cohort is more prone to develop distal  esophageal carcinoma as the BE is more in Kottayam. This data also suggests the need for GERD  registries so that high-risk population can be targeted and early intervention can lead to a decrease  in the incidence of distal esophageal carcinomas.<\/jats:p>","DOI":"10.5005\/japi-11001-0108","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:01:15Z","timestamp":1681214475000},"page":"17-20","source":"Crossref","is-referenced-by-count":0,"title":["Barrett\u2019s Esophagus: A Comparison Study between Two Cohorts of Gastroesophageal Reflux Disease"],"prefix":"10.59556","volume":"70","author":[{"given":"Krishnadas","family":"Devadas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bony","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijo","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Hareendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nibin","family":"Nahaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tharun Tom","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathan Cyriac","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2022,10,1]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:57:20Z","timestamp":1745578640000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0108_p17-20_compressed.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10,1]]},"published-print":{"date-parts":[[2022,10,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0108","relation":{},"ISSN":["0004-5772"],"issn-type":[{"type":"print","value":"0004-5772"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}