{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:17:33Z","timestamp":1777655853089,"version":"3.51.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,10,7]]},"abstract":"<jats:p>Background: HIV infection is a global pandemic. The adult HIV prevalence in India is 0.22%.  Successful therapy is transforming HIV into a chronic medical condition, and there are many  metabolic complications. This study aimed to evaluate the metabolic abnormalities in people living  with HIV (PLHIV) who were on antiretroviral therapy (ART) for at least 2 years and compare it with  ART-na\u00efve patients as well as the effect of protease inhibitor-based (PI-based) and non-protease  inhibitor-based (non-PI-based) ART was assessed. Methodology: Adult HIV-positive patients both ART-na\u00efve and on ART for more than  2 years were included. Detailed history and clinical examination, including blood pressure and  anthropometric measurements were done. This was followed by investigations like lipid profile  including total cholesterol, triglyceride, high-density lipoprotein-cholesterol (HDL-C), low-density  lipoprotein-cholesterol (LDL-C), fasting plasma glucose, and hemoglobin A1c (HbA1C) estimation.  Standard statistical tools were utilized to assess derangements and association to therapy. Results: The study was conducted for 1.5 years in a tertiary care hospital. A total of 70% of the  study population was male with mean age of participants being 43.2 years, 40% were ART-na\u00efve,  37% received non-PI-based ART, and 23% PI-based ART. The mean total cholesterol level and mean triglyceride value were significantly higher in the  PI-based ART group than in the therapy-na\u00efve group. The ART-na\u00efve group was seen to have  more subjects with abnormally low HDL-C values. The PI-based ART study subjects were found  to have a greater number of cases of glucose intolerance in relation to the rest of the two groups  significantly (p-value &lt;0.001). The LDL-C systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and  waist circumference had no association with the different ART regimens or with the HIV infection  itself. CD4 T cell count at diagnosis in the three study groups was compared with all the variables  of metabolic syndrome and no association was found. Conclusion: Total cholesterol, triglycerides, and glucose levels are the main parameters found to  be affected in PLHIV on therapy<\/jats:p>","DOI":"10.5005\/japi-11001-0109","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T12:01:15Z","timestamp":1681214475000},"page":"14-16","source":"Crossref","is-referenced-by-count":0,"title":["An Observational Study on Metabolic Derangements in People Living with HIV"],"prefix":"10.59556","volume":"70","author":[{"given":"Pallab","family":"Sinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souvik","family":"Ghatak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranab","family":"Maity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisanko","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourin","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avishek","family":"Guin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantasil","family":"Pain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotirmoy","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2022,10,1]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:57:20Z","timestamp":1745578640000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0109_p14-16_compressed.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10,1]]},"published-print":{"date-parts":[[2022,10,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0109","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}