{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:10:10Z","timestamp":1745579410978,"version":"3.40.4"},"reference-count":24,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,11,7]]},"abstract":"<jats:p>Background: A number of occupational exposures are associated with various types of renal  dysfunction. Several studies for many years have drawn attention to renal dysfunction and  nephrotoxicity among workers exposed to silica. This study was conducted to evaluate renal  dysfunction, if any, among Indian patients having silicosis and its correlation with the duration  of exposure to silica dust. Materials and methods: This study includes 52 eligible patients with a history of silica dust exposure  and silicosis confirm on radiological examination by the pneumoconiosis board. Investigations  like serum creatinine, urinary albumin creatinine ratio, etc. were done. The \u201cmodification of diet in  renal disease\u201d (MDRD) formula was used to calculate the glomerular filtration rate (GFR). Results: This study showed 53.84% of patients (n = 28) having albuminuria and a mean \u201curinary  albumin to creatinine ratio\u201d (UACR) of 101.88 \u00b1 128.99 mg\/gm. Isolated macroalbuminuria  was detected in 11.5% of patients (n = 6) while 42.3% of patients (n = 22) presented with  microalbuminuria. The mean GFR was 81.94 \u00b1 22.09 mL\/min\/1.73 m2  among study patients of  which four (7.7%) patients had GFR value &lt;60 mL\/min\/1.73 m2 . We could also identify a significant  association between the duration of exposure to silica dust and UACR and GFR (p &lt; 0.01). Conclusion: Albuminuria and reduced estimated GFR in patients with silica dust exposure is not  uncommon and reflect early underlying renal dysfunctions. Our study suggests a simple and  cost-effective screening strategy for early detection of renal dysfunction among silicosis patients  that may be considered as a tool to prevent further renal damage in such patients.<\/jats:p>","DOI":"10.5005\/japi-11001-0124","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T10:11:15Z","timestamp":1667470275000},"page":"49-52","source":"Crossref","is-referenced-by-count":0,"title":["Asymptomatic Renal Function Abnormalities in Patients having Silicosis"],"prefix":"10.59556","volume":"70","author":[{"given":"Ramakant","family":"Dixit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra","family":"Jalutharia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Leung CC, Yu IT, Chen W. 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