{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:06:55Z","timestamp":1787317615436,"version":"build-2736575974"},"reference-count":19,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,11,7]]},"abstract":"<jats:p>Background: Systemic sclerosis (SSc) is an autoimmune chronic multisystem disorder with a  plethora of cutaneous manifestations. These manifestations often may be the only presenting  complaint. Early identification of these help in diagnosing grievous systemic manifestations and  their prompt and appropriate treatment. Aims: To study the clinical profile of SSc, modified Rodnan\u2019s skin scoring (mRSS), nailfold  capillaroscopy (NFC) patterns, antibody profile in the western India population, and their  association with cutaneous manifestations. Methods: Patients of SSc fulfilling the European League Against Rheumatism (EULAR)  2013 classification of SSc criteria, who attended dermatology outpatient department (OPD)  between January 2017 and September 2018 were included in the study. The demographic data,  cutaneous features, autoantibody profile, mRSS, and NFC pattern were noted Results: A total of 60 patients (57 females and 3 males; mean age years) of SSc were evaluated.  Clinical subtypes were 40 diffuse cutaneous SSc and 20 limited cutaneous SSc. The most common  presenting symptoms were Raynaud\u2019s phenomenon (RP) (95%) and skin tightening (90%). The  common cutaneous findings were sclerodactyly (86.7%), stellate scars (78.3%), parrot-beaked  nose (76.7%), mask-like facies (75%), microstomia (56.7%), salt and pepper pigmentation (55%),  puffy finger (46.7%), telangiectasia (46.7%), digital ulcer (38.3%), fixed flexion deformity (33.3%),  and calcinosis cutis (8.33%). Limited cutaneous systemic sclerosis (lcSSc) had mRSS score of 8.3 \u00b1  4.1 and diffuse cutaneous systemic sclerosis (dcSSc) subset had a score of 28 \u00b1 10.4. Antinuclear  antibody (ANA), Anti-topoisomerase antibody (ATA), and anti-centromere antibody (ACA) were  positive in 59, 49, and 7 patients, respectively. The NFC patterns were early (23.3%), active (45%),  and late (18.3%). Limitation: The sample size of the study was small. We were not able to determine the significance  of other less common autoantibodies with scleroderma. Conclusion: The study highlights the importance of identifying early cutaneous findings and the  role of a useful diagnostic and prognostic reproducible scoring system (mRSS) and NFC.<\/jats:p>","DOI":"10.5005\/japi-11001-0136","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T06:11:15Z","timestamp":1667455875000},"page":"24-31","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous Features, Autoantibody Profile, and Nailfold Capillaroscopy of Systemic Sclerosis: A Study of 60 Cases"],"prefix":"10.59556","volume":"70","author":[{"given":"Jayati","family":"Dave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunanda","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Khadilkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Viswanath V, Phiske MM, Gopalani VV. Systemic sclerosis: current concepts in pathogenesis and therapeutic aspects of dermatological manifestations. Indian J Dermatol 2013;58(4):255-268.","DOI":"10.4103\/0019-5154.113930"},{"key":"ref-2","unstructured":"Cortes S, Cutolo M. Capillarosecopic patterns in rheumatic diseases. Acta Reum Port 2007;32(1): 29-36."},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative. Arthritis Rheum 2013;65(11):2737-2747.","DOI":"10.1002\/art.38098"},{"key":"ref-4","unstructured":"LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15(2):202-205."},{"key":"ref-5","unstructured":"Clements PJ, Lachenbruch PA, Seibold JR, et al. 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Rheumatology 2004;43(6):719-726.","DOI":"10.1093\/rheumatology\/keh156"}],"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:56:47Z","timestamp":1745564207000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0136_p24-31_compressed.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,1]]},"published-print":{"date-parts":[[2022,11,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0136","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}