{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:44:10Z","timestamp":1765547050658,"version":"3.40.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2022,12,7]]},"abstract":"<jats:p>Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the  sudden worsening of symptoms of COPD like shortness of breath, increased quantity and color  of sputum, and systemic inflammation, and has a significant impact on survival. Biomarkers such  as high-sensitivity C-reactive protein (hsCRP) and procalcitonin have been studied in AECOPD  patients as prognostic markers. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte  ratio (PLR) are two new inflammatory markers and play a significant role in prognosis in patients  with AECOPD. NLR and PLR are easily available and cost-effective markers and have the potential  for helping in the risk stratification of hospitalized AECOPD patients. Aim: Study of inflammatory markers in COPD and their correlation with clinical outcome. Methods: A prospective observational comparative study was conducted on 100 patients of  COPD at the Department of General Medicine, Vardhman Mahavir Medical College and Safdarjung  Hospital, New Delhi, and all necessary investigations were done. Results: A total of 100 patients of COPD were taken, 50 patients were in a stable state (controls)  and the same number of patients were in an acute exacerbation state (cases). Mean levels of NLR,  hsCRP, and procalcitonin in cases were significantly higher as compared to controls whereas levels  of PLR in cases and controls were comparable with no significant difference between them. Levels  of both of these inflammatory markers (NLR and PLR) were positively correlated with levels of  hsCRP and levels of procalcitonin. Of the total 50 patients, 23 (56.00%) patients needed mechanical  ventilation and 11 (22%) needed inotropic support. Only 6 out of 50 patients (12.00%) died. Levels  of NLR and PLR were positively correlated with the duration of hospitalization. Levels of NLR and  PLR were not significantly associated with the need of inotropic support and mortality, levels of  NLR were also not significantly associated with the need of mechanical ventilation whereas levels  of PLR were significantly higher in patients who required mechanical ventilation. Conclusion: Levels of NLR were raised in patients with AECOPD (cases) than stable state COPD  patients (controls). So levels of NLR can be used as a marker to predict acute exacerbation and  there was a positive correlation of NLR and PLR with levels of hsCRP and procalcitonin<\/jats:p>","DOI":"10.5005\/japi-11001-0165","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T06:31:32Z","timestamp":1681281092000},"page":"48-52","source":"Crossref","is-referenced-by-count":4,"title":["Study of Inflammatory Markers in Chronic Obstructive Pulmonary Disease"],"prefix":"10.59556","volume":"70","author":[{"given":"Bhoor","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Kampani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachcha","family":"Lall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2022,12,1]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:57:22Z","timestamp":1745578642000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0165_p48-52.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2022,12,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0165","relation":{},"ISSN":["0004-5772"],"issn-type":[{"type":"print","value":"0004-5772"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}