{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:10:11Z","timestamp":1745579411289,"version":"3.40.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:p>Aim: To study the clinico-etiological profile of children with thrombocytopenia.  Methods: This prospective hospital-based study included all children (&lt;18 years) with  thrombocytopenia at the time of hospitalization and\/or thrombocytopenia during the course  of their hospital stay. A detailed history was recorded and appropriate laboratory investigations  were carried out.  Results: The study group comprised 246 children (mean age, 9.29 years; median age, 10 years)  with male to female ratio of 1.5:1. Nearly 45% of children were above 10 years of age. Trends of  admissions showed that the majority of children with thrombocytopenia (n = 115) got hospitalized  during the rainy season, followed by summer (n = 84). Fever (72.8%), pallor (52.8%), bleeding  manifestations (22%), lymphadenopathy (20.3%), and splenomegaly (20.3%) were common  clinical features. Petechiae was the most common bleeding manifestation (63%). Septicemia (24%)  was the most common etiology, followed by megaloblastic anemia (14.6%), undiagnosed fever  (10.2%), local infection (9.3%), hepatitis (6.5%), and scrub typhus (6.1%). About nine children died.  All those who died had septicemia and multi-organ dysfunction (MOD). On logistic regression  analysis, age &gt;10 years, presence of bleeding, arthralgia, rash, pallor, gastrointestinal (GI) symptoms,  hematological disorders, and malignancy were associated with severe thrombocytopenia. Conclusion: Thrombocytopenia is a common hematological observation. This study revealed  seasonal variation in the occurrence of thrombocytopenia in children, with the maximum number  of cases in the rainy season. Septicemia is the commonest etiology. The majority of children  with thrombocytopenia have no bleeding manifestations. Age &gt;10 years, presence of bleeding,  arthralgia, rash, pallor, GI symptoms, hematological disorders, and malignancy are associated  with severe thrombocytopenia.<\/jats:p>","DOI":"10.5005\/japi-11001-0198","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T06:12:15Z","timestamp":1681366335000},"page":"37-41","source":"Crossref","is-referenced-by-count":0,"title":["Thrombocytopenia in Children: A Large Prospective Study on Clinical Manifestations, Seasonal Variation, Etiology, and Outcome"],"prefix":"10.59556","volume":"71","author":[{"given":"Isha","family":"Bhatia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandesh","family":"Guleria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranbir S","family":"Jaswal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Vaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Rehalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2023,3,1]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:57:06Z","timestamp":1745578626000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0198_p37-41_compressed.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,3,1]]},"published-print":{"date-parts":[[2023,3,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0198","relation":{},"ISSN":["0004-5772"],"issn-type":[{"type":"print","value":"0004-5772"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}