{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:04:56Z","timestamp":1745640296723,"version":"3.40.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2023,5,7]]},"abstract":"<jats:p>Dermatophytosis is a very common public health problem with high prevalence. Dermatophytes  are a highly specialized set of filamentous fungi, which are adapted to keratinized tissues of  humans and animals. Dermatophytosis is the most common fungal infection worldwide, affecting  approximately 20\u201325% of the world\u2019s population. The etiological agents of dermatophytosis,  called dermatophytes, change with geography and socioeconomic status. Trichophyton rubrum (T. rubrum) is the prime species for skin and nail infections followed by T. mentagrophytes\/ T. interdigital complex. There is a shift from T. rubrum to T. mentagrophytes in India for superficial  fungal infections. In order to deal with fungal infections, treatment strategies involve the use of  systemic antifungals and\/or topical antifungal agents. Naftifine is a synthetic allylamine antifungal  first reported in 1974 and in 1985 became the first commercially available allylamine. The highly  lipophilic nature of allylamine allows efficient penetration and reasonably high concentrations  in the stratum corneum (SC) and hair follicles. Naftifine is fungicidal as well as fungistatic. The  higher efficacy rates of allylamines over imidazoles for the treatment of fungal infections, even for  months after cessation of treatment, is thought to be due to their fungicidal effect, as well as to  potentially greater keratin binding and slower release from the SC. The effectiveness of naftifine is  also demonstrated against various bacteria belonging to both gram-negative and gram-positive  classes. The antiinflammatory property of naftifine has been reported in various preclinical studies  where it has been shown to target the prostaglandin pathway. Naftifine 1 and 2% gel and cream  is approved by The United States Food and Drug Administration (USFDA), recently naftifine has  been approved in India by the Indian regulatory authority Drug Controller General of India (DCGI)  for the treatment of dermatophytosis. Naftifine 2% also appears to be a promising treatment,  requiring fewer applications than the 1% formulation. Naftifine appears to be effective in a single  dose and has a shorter treatment duration than azoles. Naftifine demonstrated its efficacy and  safety in various clinical studies of tinea infections. Naftifine offers a very useful and promising  option for treating dermatophytosis.<\/jats:p>","DOI":"10.5005\/japi-11001-0241","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T06:35:10Z","timestamp":1686638110000},"page":"80-85","source":"Crossref","is-referenced-by-count":6,"title":["Naftifine: A Topical Allylamine for Superficial  Dermatophytosis"],"prefix":"10.59556","volume":"71","author":[{"given":"Abhijit A","family":"Trailokya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar B","family":"Shirsat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Madhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2023,5,1]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:57:30Z","timestamp":1745578650000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/files\/JAPI0241_p80-85_compressed.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,5,1]]},"published-print":{"date-parts":[[2023,5,7]]}},"URL":"https:\/\/doi.org\/10.5005\/japi-11001-0241","relation":{},"ISSN":["0004-5772"],"issn-type":[{"type":"print","value":"0004-5772"}],"subject":[],"published":{"date-parts":[[2023,5,1]]}}}