{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:21:06Z","timestamp":1776777666658,"version":"3.51.2"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Aim<\/jats:title>\n<jats:p>The objective of this report is to present the clinical experiences of several patients affected with osteonecrosis (ONJ) secondary to bisphosphonate (BP) therapy and to provide a discussion of the specific BPs implicated in this condition.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>ONJ secondary to BP therapy is becoming an increasingly reported complication following dental therapy. This is particularly true of surgical dental procedures such as extractions. BPs are a class of pharmaceuticals used in the treatment of numerous disorders affecting bone, including osteoporosis, cancer metastases to bone, hypercalcemia of malignancy, and multiple myeloma. Although ONJ is a more recently described phenomenon, it is an emerging problem that may be associated with significant morbidity such as oral dysfunction, impaired eating ability, pain, and compromised esthetics resulting in a poor quality of life in affected patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case Report<\/jats:title>\n<jats:p>This is a description of 13 patients affected with ONJ secondary to BP therapy managed at the Orofacial Pain &amp; Oral Medicine Center, Special Patients Clinic, and Oral and Maxillofacial Surgery Clinic at the University of Southern California, School of Dentistry between October 2005 and April 2007, with a discussion of the specific BPs implicated in this condition, the clinical presentation, management, and follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Summary<\/jats:title>\n<jats:p>Thorough reporting of every case of ONJ is important to help advance the understanding of this poorly understood condition. The authors\u2019 approach to care represents a more conservative mode to management than previously described by many investigators.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Citation<\/jats:title>\n<jats:p>Kumar SKS, Meru MC, Sedghizadeh PP. Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy: A Case Series. J Contemp Dent Pract 2008 January;(9)1:063-069.<\/jats:p>\n<\/jats:sec>","DOI":"10.5005\/jcdp-9-1-63","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T12:53:46Z","timestamp":1563368026000},"page":"63-69","source":"Crossref","is-referenced-by-count":13,"title":["Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy: A Case Series"],"prefix":"10.5005","volume":"9","author":[{"given":"Satish K. S.","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Meru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parish P.","family":"Sedghizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2008]]},"container-title":["The Journal of Contemporary Dental Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.thejcdp.com\/doi\/pdf\/10.5005\/jcdp-9-1-63","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T12:50:53Z","timestamp":1609419053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.thejcdp.com\/doi\/10.5005\/jcdp-9-1-63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008]]}},"alternative-id":["10.5005\/jcdp-9-1-63"],"URL":"https:\/\/doi.org\/10.5005\/jcdp-9-1-63","relation":{},"ISSN":["1526-3711"],"issn-type":[{"value":"1526-3711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}