{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T23:48:05Z","timestamp":1749685685016},"reference-count":11,"publisher":"The Editorial Office of Gut and Liver","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut Liver"],"published-print":{"date-parts":[[2016,1,23]]},"DOI":"10.5009\/gnl15576","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T06:15:31Z","timestamp":1450851331000},"page":"10","source":"Crossref","is-referenced-by-count":2,"title":["Reappraisal of Antihypertensive Medicine Doxazosin and Carvedilol as a Potential Therapeutic for Hepatic Fibrosis"],"prefix":"10.5009","volume":"10","author":[{"given":"Yong-Han","family":"Paik","sequence":"first","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,Seoul, Korea"},{"name":"Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2920","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1089\/ars.2013.5619","article-title":"Role of NADPH oxidases in liver fibrosis","volume":"20","author":"Paik, YH","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-0035-1550055","article-title":"Antifibrotic therapies in the liver","volume":"35","author":"Mehal, WZ","year":"2015","journal-title":"Semin Liver Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1478-3231.2012.02774.x","article-title":"Beneficial effects of candesartan, an angiotensin-blocking agent, on compensated alcoholic liver fibrosis: a randomized open-label controlled study","volume":"32","author":"Kim, MY","year":"2012","journal-title":"Liver Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5009\/gnl14459","article-title":"Doxazosin treatment attenuates carbon tetrachloride-induced liver fibrosis in hamsters through a decrease in transforming growth factor beta secretion","volume":"10","author":"Mu\u00f1oz-Ortega, MH","year":"2016","journal-title":"Gut Liver"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters","volume":"53","author":"Oben, JA","year":"2004","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"G877","DOI":"10.1152\/ajpgi.00537.2005","article-title":"Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells","volume":"291","author":"Sancho-Bru, P","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e72928","DOI":"10.1371\/journal.pone.0072928","article-title":"Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells","volume":"8","author":"Sigala, B","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/00912700022008649","article-title":"Cardiovascular drug therapy in patients with hepatic diseases and patients with congestive heart failure","volume":"40","author":"Sokol, SI","year":"2000","journal-title":"J Clin Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/hep.1840360612","article-title":"Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis","volume":"36","author":"Ba\u00f1ares, R","year":"2002","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1053\/j.gastro.2014.03.005","article-title":"Nonselective beta blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis","volume":"146","author":"Mandorfer, M","year":"2014","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/gutjnl-2013-306502","article-title":"Non-selective beta-blockers are associated with improved survival in patients with ascites listed for liver transplantation","volume":"64","author":"Leithead, JA","year":"2015","journal-title":"Gut"}],"container-title":["Gut and Liver"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/ekjg\/ekjg010-01-05.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T02:22:07Z","timestamp":1498270927000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl15576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,23]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,23]]}},"alternative-id":["10.5009\/gnl15576"],"URL":"https:\/\/doi.org\/10.5009\/gnl15576","relation":{},"ISSN":["1976-2283","2005-1212"],"issn-type":[{"value":"1976-2283","type":"print"},{"value":"2005-1212","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,23]]}}}