{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:56:04Z","timestamp":1790808964934,"version":"4.1.0"},"reference-count":99,"publisher":"The Editorial Office of Gut and Liver","issue":"5","license":[{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.gutnliver.org"],"crossmark-restriction":true},"short-container-title":["Gut and Liver"],"published-print":{"date-parts":[[2019,9,15]]},"DOI":"10.5009\/gnl18449","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T04:42:25Z","timestamp":1553748145000},"page":"498-505","update-policy":"https:\/\/doi.org\/10.5009\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Familial Pancreatic Cancer and Surveillance of High-Risk Individuals"],"prefix":"10.5009","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-2351","authenticated-orcid":false,"given":"Hiroyuki","family":"Matsubayashi","sequence":"first","affiliation":[{"name":"Divisions of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan"},{"name":"Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoichi","family":"Takaori","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chigusa","family":"Morizane","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Kiyozumi","sequence":"additional","affiliation":[{"name":"Divisions of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2920","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9658-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24794"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000563"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg062"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114972"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026580131793"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10863"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182156e1b"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3823"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.09.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20228"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09524.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-007-9166-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000915)87:6<809::AID-IJC8>3.0.CO;2-U"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-9549-8"},{"key":"ref16","unstructured":"Murphy KM, Brune KA, Griffin C, et al. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res 2002;62:3789-3793."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1529"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.10.1394"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i6.935"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1517\/14796694.1.2.191"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp466"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000108962"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0923-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00013-8"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-010-9414-x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.171611"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065045"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28863"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200404000-00008"},{"key":"ref32","unstructured":"Brune K, Abe T, Canto M, et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 2006;30:1067-1076."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0004"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.04.003"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0471"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-014-9755-y"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0630"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0194"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.2.7136"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.01.032"},{"key":"ref41","unstructured":"Goggins M, Schutte M, Lu J, et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996;56:5360-5364."},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-7850-4"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171202"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01425.x"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12490"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3377-4"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31815c75ea"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1457"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1605"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208411"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.10.015"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1999.tb00825.x"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0734"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.04.016"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.004"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-013-0611-5"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.108456"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303108"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2012.04.004"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318258055c"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000052"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp134"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22535"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm361"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602619"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282001"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01075.x"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090992"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.02.005"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2011.01113.x"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.09.018"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(01)70082-X"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.01.005"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-4-199908170-00003"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17703"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.035"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3449"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001693"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815c2ca3"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000181"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.050"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-006-0025-7"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00244-7"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.276"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3209"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.65"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.048"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1781-6"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.3852"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0730"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00141-0"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.8545"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2728"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.418"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.220"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2788-6"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24865"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00042"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.0812"}],"container-title":["Gut and Liver"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/GNL\/2019\/013\/GNL013-05-04.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"http:\/\/pdf.medrang.co.kr\/GNL\/2019\/013\/GNL013-05-04.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T02:24:50Z","timestamp":1569291890000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl18449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,15]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9,15]]}},"alternative-id":["10.5009\/gnl18449"],"URL":"https:\/\/doi.org\/10.5009\/gnl18449","relation":{},"ISSN":["1976-2283","2005-1212"],"issn-type":[{"value":"1976-2283","type":"print"},{"value":"2005-1212","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,15]]},"assertion":[{"value":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl18449","URL":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl18449","name":"the_journal","label":"Gut and Liver","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2018-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"http:\/\/orcid.org\/0000-0002-7050-2351","URL":"http:\/\/orcid.org\/0000-0002-7050-2351","name":"author","label":"Hiroyuki Matsubayashi","group":{"name":"orcid","label":"ORCID"}},{"value":"\u00a9 2019 The Editorial Office of Gut and Liver","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}