{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:26:40Z","timestamp":1778797600495,"version":"3.51.4"},"reference-count":69,"publisher":"The Editorial Office of Gut and Liver","issue":"3","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.gutnliver.org"],"crossmark-restriction":true},"short-container-title":["Gut and Liver"],"published-print":{"date-parts":[[2021,5,15]]},"DOI":"10.5009\/gnl19418","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T05:38:35Z","timestamp":1587620315000},"page":"338-345","update-policy":"https:\/\/doi.org\/10.5009\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characteristics and Early Diagnosis of Gastric Cancer Discovered after <i>Helicobacter pylori<\/i> Eradication"],"prefix":"10.5009","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-9059","authenticated-orcid":false,"given":"Masanori","family":"Ito","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-3957","authenticated-orcid":false,"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-5341","authenticated-orcid":false,"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2920","reference":[{"key":"ref1","unstructured":"International Agency for Research on Cancer (IARC). GLOBOCAN 2012 Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. IARC: Lyon, 2014."},{"key":"ref2","unstructured":"Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994;61:1-241."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00889.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000339176"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12415"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0036-8"},{"key":"ref8","unstructured":"Uemura N, Mukai T, Okamoto S, et al. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol Biomarkers Prev 1997;6:639-642."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw132"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001195"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183321"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0876-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000335260"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0682-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/BF01887370"},{"key":"ref19","unstructured":"Matsui T, Yao T. Natural history of gastric cancer. Nihon Rinsho 2001;59 Suppl 4:583-588."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1586\/era.09.160"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02459.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000485504"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000496692"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02360.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.08.013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/BF01612665"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF02779205"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2427-6"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000088396"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000181146"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000636"},{"key":"ref32","unstructured":"Kitadai Y, Haruma K, Mukaida N, et al. Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. Clin Cancer Res 2000;6:2735-2740."},{"key":"ref33","unstructured":"Gotoda T, Saito D, Kondo H, et al. Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori. J Gastroenterol 1999;34 Suppl 11:91-96."},{"key":"ref34","unstructured":"Ito M, Kotachi T, Boda T, et al. Endoscopic and histological feature of gastric cancer discovered after Helicobacter pylori eradication therapy; can the eradication therapy of Helicobacter pylori normalize gastric tumor? Stomach Intestine 2016;51:759-765."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12218"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12132"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3887-2"},{"key":"ref39","unstructured":"Nimura S, Saka A, Yagi K. Gastric cancer discovered after Helicobacter pylori eradication-Histopathological features. Stomach Intestine 2016;51:742-749."},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01596-4"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13969"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.033"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301647"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.08.030"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16357"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1159\/000494414"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/den.12031"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.4021\/gr357w"},{"key":"ref49","unstructured":"Haruma K. Kyoto classification of gastritis. Nihon Medical Center: Tokyo, 2017, 2017."},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/den.12581"},{"key":"ref51","unstructured":"Yao K, Nagahama T, So S, et al. Morphological correlation between ordinary and magnifying endoscopic findings with regard to small, depressed type gastric cancers. Stomach Intestine 2006;41:781-794."},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1159\/000487045"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214594"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3649705"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4676-x"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.08.049"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1159\/000489167"},{"key":"ref58","unstructured":"Kawai T, Ito M, Aoyama N, et al. Evaluation of gastric cancer risk by optimized serum antibody titers against H. pylori: a multi-center retrospective study. Jpn J Helicobacter Res 2018;19:133-138."},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.02.026"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.791"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163700"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5211-4"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30145"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0544-6"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31667"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0803-4"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313387"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307094"}],"container-title":["Gut and Liver"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/GNL\/2021\/015\/GNL015-03-338.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/GNL\/2021\/015\/GNL015-03-338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T07:03:52Z","timestamp":1622012632000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl19418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5,15]]}},"alternative-id":["10.5009\/gnl19418"],"URL":"https:\/\/doi.org\/10.5009\/gnl19418","relation":{},"ISSN":["1976-2283","2005-1212"],"issn-type":[{"value":"1976-2283","type":"print"},{"value":"2005-1212","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]},"assertion":[{"value":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl19418","URL":"http:\/\/www.gutnliver.org\/journal\/view.html?doi=10.5009\/gnl19418","name":"the_journal","label":"Gut and Liver","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-24","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-15","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"https:\/\/orcid.org\/0000-0002-8218-9059","URL":"https:\/\/orcid.org\/0000-0002-8218-9059","name":"author","label":"Masanori Ito","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0002-0480-3957","URL":"https:\/\/orcid.org\/0000-0002-0480-3957","name":"author","label":"Shinji Tanaka","group":{"name":"orcid","label":"ORCID"}},{"value":"https:\/\/orcid.org\/0000-0002-5530-5341","URL":"https:\/\/orcid.org\/0000-0002-5530-5341","name":"author","label":"Kazuaki Chayama","group":{"name":"orcid","label":"ORCID"}},{"value":"\u00a9 2021 The Editorial Office of Gut and Liver","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}