{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T19:39:50Z","timestamp":1770579590528,"version":"3.49.0"},"reference-count":37,"publisher":"XMLink","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["Ann Dermatol"],"published-print":{"date-parts":[[2019]]},"DOI":"10.5021\/ad.2019.31.6.611","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T06:27:29Z","timestamp":1573540049000},"page":"611","update-policy":"https:\/\/doi.org\/10.5021\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Novel Effect of Lipids Extracted from Vernix Caseosa on Regulation of Filaggrin Expression in Human Epidermal Keratinocytes"],"prefix":"10.5021","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0782-4478","authenticated-orcid":false,"given":"Wu","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7571","authenticated-orcid":false,"given":"Tinghan","family":"Jia","sequence":"additional","affiliation":[{"name":"Pigeon Maternal & Infant Skin Care Research Institute, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-2431","authenticated-orcid":false,"given":"Hongjian","family":"Gu","sequence":"additional","affiliation":[{"name":"Pigeon Maternal & Infant Skin Care Research Institute, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-886X","authenticated-orcid":false,"given":"Ruihua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-2078","authenticated-orcid":false,"given":"Ken","family":"Kaku","sequence":"additional","affiliation":[{"name":"Pigeon Maternal & Infant Skin Care Research Institute, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-8582","authenticated-orcid":false,"given":"Wenhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18617","reference":[{"key":"10.5021\/ad.2019.31.6.611_ref1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.alit.2017.08.004","volume":"66","author":"Yamazaki","year":"2017","journal-title":"Allergol Int"},{"key":"10.5021\/ad.2019.31.6.611_ref2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"issue":"3 Pt 2","key":"10.5021\/ad.2019.31.6.611_ref3","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref4","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"10.5021\/ad.2019.31.6.611_ref5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4172\/2155-9899.1000110","volume":"2","author":"Brandt","year":"2011","journal-title":"J Clin Cell Immunol"},{"key":"10.5021\/ad.2019.31.6.611_ref6","doi-asserted-by":"crossref","first-page":"e3664","DOI":"10.1371\/journal.pone.0003664","volume":"3","author":"Brown","year":"2008","journal-title":"PLoS One"},{"key":"10.5021\/ad.2019.31.6.611_ref7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2006.06.005","volume":"27","author":"Sutmuller","year":"2006","journal-title":"Trends Immunol"},{"key":"10.5021\/ad.2019.31.6.611_ref8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1467-2494.2006.00338.x","volume":"28","author":"Hoath","year":"2006","journal-title":"Int J Cosmet Sci"},{"key":"10.5021\/ad.2019.31.6.611_ref9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1203\/PDR.0b013e318067b442","volume":"62","author":"Tansirikongkol","year":"2007","journal-title":"Pediatr Res"},{"key":"10.5021\/ad.2019.31.6.611_ref10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1525-1470.2000.01770.x","volume":"17","author":"Bautista","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000328744","volume":"24","author":"Visscher","year":"2011","journal-title":"Skin Pharmacol Physiol"},{"key":"10.5021\/ad.2019.31.6.611_ref12","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/pr.2017.297","volume":"83","author":"Yan","year":"2018","journal-title":"Pediatr Res"},{"key":"10.5021\/ad.2019.31.6.611_ref13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/BF02531942","volume":"4","author":"Fu","year":"1969","journal-title":"Lipids"},{"key":"10.5021\/ad.2019.31.6.611_ref14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.0022-202x.2001.01399.x","volume":"117","author":"Fluhr","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1034\/j.1600-0463.2001.d01-131.x","volume":"109","author":"Bergsson","year":"2001","journal-title":"APMIS"},{"key":"10.5021\/ad.2019.31.6.611_ref16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1194\/jlr.M079186","volume":"59","author":"Boiten","year":"2018","journal-title":"J Lipid Res"},{"key":"10.5021\/ad.2019.31.6.611_ref17","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1007\/s00018-005-5260-7","volume":"62","author":"Tollin","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.5021\/ad.2019.31.6.611_ref18","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1128\/AAC.42.9.2290","volume":"42","author":"Bergsson","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.5021\/ad.2019.31.6.611_ref19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000069757","volume":"16","author":"Wille","year":"2003","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.5021\/ad.2019.31.6.611_ref20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"issue":"Pt 9","key":"10.5021\/ad.2019.31.6.611_ref21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"10.5021\/ad.2019.31.6.611_ref22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.5021\/ad.2018.30.6.645","volume":"30","author":"Choi","year":"2018","journal-title":"Ann Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref23","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF02505232","volume":"288","author":"Seguchi","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"10.5021\/ad.2019.31.6.611_ref24","first-page":"651","volume":"58","author":"Tansirikongkol","year":"2007","journal-title":"J Cosmet Sci"},{"key":"10.5021\/ad.2019.31.6.611_ref25","first-page":"547","volume":"12","author":"Lee","year":"2014","journal-title":"Korean J Aesthet Cosmetol"},{"key":"10.5021\/ad.2019.31.6.611_ref26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11882-014-0433-9","volume":"14","author":"Agrawal","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.5021\/ad.2019.31.6.611_ref27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/exd.13116","volume":"26","author":"Berkers","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jdermsci.2015.09.012","volume":"80","author":"Wallmeyer","year":"2015","journal-title":"J Dermatol Sci"},{"key":"10.5021\/ad.2019.31.6.611_ref29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.20051745","volume":"203","author":"Liu","year":"2006","journal-title":"J Exp Med"},{"key":"10.5021\/ad.2019.31.6.611_ref30","doi-asserted-by":"crossref","first-page":"e99173","DOI":"10.1371\/journal.pone.0099173","volume":"9","author":"M\u00edkov\u00e1","year":"2014","journal-title":"PLoS One"},{"key":"10.5021\/ad.2019.31.6.611_ref31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaci.2015.04.026","volume":"136","author":"Kim","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.5021\/ad.2019.31.6.611_ref32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.jid.5700559","volume":"127","author":"Miller","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"10.5021\/ad.2019.31.6.611_ref34","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/bjd.14012","volume":"173","author":"Rouaud-Tinguely","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.5021\/ad.2019.31.6.611_ref35","doi-asserted-by":"crossref","first-page":"e9258","DOI":"10.1371\/journal.pone.0009258","volume":"5","author":"Dumortier","year":"2010","journal-title":"PLoS One"},{"key":"10.5021\/ad.2019.31.6.611_ref36","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nm.2062","volume":"15","author":"Lai","year":"2009","journal-title":"Nat Med"},{"key":"10.5021\/ad.2019.31.6.611_ref37","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/jid.2014.83","volume":"134","author":"Danso","year":"2014","journal-title":"J Invest Dermatol"}],"container-title":["Annals of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.5021\/ad.2019.31.6.611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T21:36:09Z","timestamp":1612301769000},"score":1,"resource":{"primary":{"URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.5021\/ad.2019.31.6.611","relation":{},"ISSN":["1013-9087","2005-3894"],"issn-type":[{"value":"1013-9087","type":"print"},{"value":"2005-3894","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.2019.31.6.611","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2019-05-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2019 The Korean Dermatological Association and The Korean Society for Investigative Dermatology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}