{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:58:36Z","timestamp":1790798316891,"version":"4.1.0"},"reference-count":21,"publisher":"XMLink","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Incospharm Corp"}],"content-domain":{"domain":["anndermatol.org"],"crossmark-restriction":false},"short-container-title":["Ann Dermatol"],"published-print":{"date-parts":[[2025]]},"DOI":"10.5021\/ad.25.079","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T23:42:31Z","timestamp":1755560551000},"page":"294","update-policy":"https:\/\/doi.org\/10.5021\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of a PTPD-12\u2013Containing Cream on Improvement in Hyperpigmentation: A Randomized, Split-Face Clinical Trial"],"prefix":"10.5021","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-600X","authenticated-orcid":false,"given":"Yu Jeong","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0202-7800","authenticated-orcid":false,"given":"Shinwon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-6829","authenticated-orcid":false,"given":"Il Joo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0927-5540","authenticated-orcid":false,"given":"Jamal Mohammed","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-2652","authenticated-orcid":false,"given":"Eun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-321X","authenticated-orcid":false,"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6649-308X","authenticated-orcid":false,"given":"Seohyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-1400","authenticated-orcid":false,"given":"Sang Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.5021\/ad.25.079_ref1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1096\/fj.06-6649rev","volume":"21","author":"Costin","year":"2007","journal-title":"FASEB J"},{"key":"10.5021\/ad.25.079_ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1586\/edm.10.70","volume":"6","author":"Kondo","year":"2011","journal-title":"Expert Rev Dermatol"},{"key":"10.5021\/ad.25.079_ref3","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.3390\/molecules28124839","volume":"28","author":"Thawabteh","year":"2023","journal-title":"Molecules"},{"key":"10.5021\/ad.25.079_ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5021\/ad.23.133","volume":"36","author":"Jo","year":"2024","journal-title":"Ann Dermatol"},{"key":"10.5021\/ad.25.079_ref5","doi-asserted-by":"crossref","first-page":"11289","DOI":"10.3390\/ijms241411289","volume":"24","author":"Bento-Lopes","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.5021\/ad.25.079_ref6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/tra.12843","volume":"23","author":"Moreiras","year":"2022","journal-title":"Traffic"},{"key":"10.5021\/ad.25.079_ref7","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.biocel.2010.03.023","volume":"42","author":"Schiaffino","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.5021\/ad.25.079_ref8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.5021\/ad.25.079_ref9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.5021\/ad.25.079_ref10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1755-148X.2011.00889.x","volume":"24","author":"Ho","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.5021\/ad.25.079_ref11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jid.2017.09.042","volume":"138","author":"Correia","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.5021\/ad.25.079_ref12","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.3390\/ijms22094466","volume":"22","author":"Moreiras","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.5021\/ad.25.079_ref13","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/jid.2013.165","volume":"133","author":"Murase","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.5021\/ad.25.079_ref14","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/cells11192999","volume":"11","author":"Kovacs","year":"2022","journal-title":"Cells"},{"key":"10.5021\/ad.25.079_ref15","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.3390\/ijms21165708","volume":"21","author":"Murase","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.5021\/ad.25.079_ref16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/pcmr.12838","volume":"33","author":"Kim","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.5021\/ad.25.079_ref17","doi-asserted-by":"crossref","first-page":"844756","DOI":"10.3389\/fphar.2022.844756","volume":"13","author":"Klapan","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.5021\/ad.25.079_ref18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/cosmetics11060223","volume":"11","author":"Eun","year":"2024","journal-title":"Cosmetics"},{"key":"10.5021\/ad.25.079_ref19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jocd.13636","volume":"20","author":"Lee","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"10.5021\/ad.25.079_ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/srt.12145","volume":"21","author":"Nam","year":"2015","journal-title":"Skin Res Technol"},{"key":"10.5021\/ad.25.079_ref21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1365-2133.2001.03958.x","volume":"144","author":"Roh","year":"2001","journal-title":"Br J Dermatol"}],"container-title":["Annals of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/anndermatol.org\/pdf\/10.5021\/ad.25.079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.25.079","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.25.079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:58:13Z","timestamp":1758952693000},"score":1,"resource":{"primary":{"URL":"https:\/\/anndermatol.org\/DOIx.php?id=10.5021\/ad.25.079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5021\/ad.25.079","relation":{},"ISSN":["1013-9087","2005-3894"],"issn-type":[{"value":"1013-9087","type":"print"},{"value":"2005-3894","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"2025-05-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-30","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 The Korean Dermatological Association and The Korean Society for Investigative Dermatology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}