{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:27:05Z","timestamp":1730870825806,"version":"3.28.0"},"reference-count":21,"publisher":"Rambam Health Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rambam Maimonides Med J"],"abstract":"<jats:p>Purpose: This case series analyzed the appropriateness of computed tomography (CT) and magnetic resonance imaging (MRI) for visualization of rhinoorbitocerebral mucormycosis (ROCM) patterns associ-ated with type 2 diabetes (T2D) post-recovery from coronavirus disease 2019 (COVID-19). Methods: The study included 24 patients with invasive ROCM after having recovered from COVID-19. All patients underwent CT examinations and microbiological and histological verification; 5 patients under-went MRI. Results: The CT and MRI patterns noted in our patients revealed involvement of skull orbits, paranasal sinuses, large arteries, and optic nerves, with intracranial spread and involvement of the cranial base bones. Using brain scan protocol for CT provided better soft-tissue resolution. We found that extending the MRI protocol by T2-sequence with fat suppression or STIR was better for periantral fat and muscle evaluations. Conclusion: Computed tomography of the paranasal sinuses is the method of choice for suspected fungal infections, particularly mucormycosis. However, MRI is recommended if there is suspicion of orbital, vascular, or intracranial complications, including cavernous sinus extension. The combination of both CT and MRI enables determination of soft tissue invasion and bony destruction, thereby facilitating the choice of an optimal ROCM treatment strategy. Invasive fungal infections are extremely rare in Europe; most of the related data are provided from India and Middle Eastern or African nations. Hence, this study is notable in its use of only diagnosed ROCM cases in Russia.<\/jats:p>","DOI":"10.5041\/rmmj.10483","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T07:25:02Z","timestamp":1666855502000},"page":"e0024","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Imaging in Rhinoorbitocerebral Mucormycosis Associated with Type 2 Diabetes After COVID-19"],"prefix":"10.5041","volume":"13","author":[{"name":"Radiology Department, Clinic of Samara State Medical University, Samara, Russia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel Mikhailovich","family":"Zelter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Radiology, Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olesya Vladimirovna","family":"Zeleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Otorhinolaryngology Department, Clinic of Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egor Andreevich","family":"Sidorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Radiology Department, Clinic of Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy Vyacheslavovich","family":"Solovov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Radiology Department, Clinic of Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Radiology, Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniy Nikolaevich","family":"Surovtsev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Radiology, Samara State Medical University, Samara, Russia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2983","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"1. Klimko NN, Khostelidi SN, Shadrivova OV, et al. Mucormycosis in oncohematology patients (results of the prospective study). Onkogematologi\u00e2 2017;12:14-22(9). [Russian].","key":"ref0","DOI":"10.17650\/1818-8346-2017-12-2-14-22"},{"doi-asserted-by":"publisher","unstructured":"2. Hoenigl M, Seidel D, Carvalho A, et al. The emergence of COVID-19 associated mucormycosis: analysis of cases from 18 countries (May 12, 2021). Available at SSRN: https:\/\/ssrn.com\/abstract=3844587 or (accessed September 11, 2022).","key":"ref1","DOI":"10.2139\/ssrn.3844587"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"102146","DOI":"10.1016\/j.dsx.2021.05.019","article-title":"Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India","volume":"15","author":"Singh","year":"2021","unstructured":"3. Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15:102146.","journal-title":"Diabetes Metab Syndr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4274\/tjo.82474","article-title":"Rhino-orbital mucormycosis: clinical findings and treatment outcomes of four cases","volume":"45","author":"U\u011furlu \u015e","year":"2015","unstructured":"4. Karadeniz U\u011furlu \u015e, Selim S, Kopar A, Songu M. Rhino-orbital mucormycosis: clinical findings and treatment outcomes of four cases. Turk J Ophthalmol 2015;45:169-74.","journal-title":"Turk J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.4103\/ijo.IJO_1165_21","article-title":"Code mucor: guidelines for the diagnosis, staging and management of rhino-orbito-cerebral mucormycosis in the setting of COVID-19","volume":"69","author":"Honavar","year":"2021","unstructured":"5. Honavar SG. Code mucor: guidelines for the diagnosis, staging and management of rhino-orbito-cerebral mucormycosis in the setting of COVID-19. Indian J Ophthalmol 2021;69:1361-5.","journal-title":"Indian J Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.4103\/ijo.IJO_1439_21","article-title":"Magnetic resonance imaging in rhino-orbital-cerebral mucormycosis","volume":"69","author":"Sreshta","year":"2021","unstructured":"6. Sreshta K, Dave TV, Varma DR, et al. Magnetic resonance imaging in rhino-orbital-cerebral mucormycosis. Indian J Ophthalmol 2021;69:1915-27.","journal-title":"Indian J Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.3174\/ajnr.A4298","article-title":"Acute invasive fungal rhinosinusitis: a comprehensive update of CT findings and design of an effective diagnostic imaging model","volume":"36","author":"Middlebrooks","year":"2015","unstructured":"7. Middlebrooks EH, Frost CJ, De Jesus RO, Massini TC, Schmalfuss IM, Mancuso AA. Acute invasive fungal rhinosinusitis: a comprehensive update of CT findings and design of an effective diagnostic imaging model. AJNR Am J Neuroradiol 2015;36:1529-35.","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1177\/0284185120988828","article-title":"Imaging features of rhinocerebral mucormycosis: from onset to vascular complications","volume":"63","author":"Mazzai","year":"2022","unstructured":"8. Mazzai L, Anglani M, Giraudo C, Martucci M, Cester G, Causin F. Imaging features of rhinocerebral mucormycosis: from onset to vascular complications. Acta Radiol 2022;63:232-44.","journal-title":"Acta Radiol"},{"doi-asserted-by":"publisher","unstructured":"9. Kumar Gg S, Deepalam S, Siddiqui A, et al. Coronavirus disease 2019 (COVID-19)-associated rhino-orbito-cerebral mucormycosis: a multi-institutional retrospective study of imaging patterns. World Neurosurg 2022:162:e131-40.","key":"ref8","DOI":"10.1016\/j.wneu.2022.02.107"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: a review of 929 reported cases","volume":"41","author":"Roden","year":"2005","unstructured":"10. Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 2005;41:634-53.","journal-title":"Clin Infect Dis"},{"unstructured":"11. Cappello ZJ, Minutello K, Dublin AB. Anatomy, Head and Neck, Nose Paranasal Sinuses. [Updated Mar 25, 2022]. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2022 Jan. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499826\/ (accessed October 3, 2022).","key":"ref10"},{"unstructured":"12. Chan LL, Singh S, Jones D, Diaz EM Jr, Ginsberg LE. Imaging of mucormycosis skull base osteomyelitis. AJNR Am J Neuroradiol 2000;21:828-31. PMID: 10815656","key":"ref11"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12886-016-0189-1","article-title":"A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially","volume":"16","author":"Jiang","year":"2016","unstructured":"13. Jiang N, Zhao G, Yang S, et al. A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially. BMC Ophthalmol 2016;16:10.","journal-title":"BMC Ophthalmol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.21037\/qims.2018.11.08","article-title":"Imaging of cerebrovascular complications of infection","volume":"8","author":"Shen","year":"2018","unstructured":"14. Shen G, Shen X, Pu W, Zhang G, Lerner A, Gao B. Imaging of cerebrovascular complications of infection. Quant Imaging Med Surg 2018;8:1039-51.","journal-title":"Quant Imaging Med Surg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3174\/ajnr.A1315","article-title":"MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging","volume":"30","author":"Kapur","year":"2009","unstructured":"15. Kapur R, Sepahdari AR, Mafee MF, et al. MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging. AJNR Am J Neuroradiol 2009;30: 64-70.","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4103\/0975-5950.111392","article-title":"Traumatic superior orbital fissure syndrome: review of literature and report of three cases","volume":"3","author":"Rai","year":"2012","unstructured":"16. Rai S, Rattan V. Traumatic superior orbital fissure syndrome: review of literature and report of three cases. Natl J Maxillofac Surg 2012;3:222-5.","journal-title":"Natl J Maxillofac Surg"},{"doi-asserted-by":"publisher","unstructured":"17. Sotoudeh H, Shafaat O, Aboueldahab N, Vaphiades M, Sotoudeh E, Bernstock J. Superior ophthalmic vein thrombosis: what radiologist and clinician must know? Eur J Radiol Open 2019;6:258-64.","key":"ref16","DOI":"10.1016\/j.ejro.2019.07.002"},{"doi-asserted-by":"publisher","unstructured":"18. de Moura Feitoza L, Altemani A, Adolfo da Silva N Jr, Reis F. Teaching neuroimages: mucormycosis-associated vasculitis: a new sequence to show an old invasive infection. Neurology 2019;92:e1796-7.","key":"ref17","DOI":"10.1212\/WNL.0000000000007275"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.4103\/0976-3147.158790","article-title":"Bilateral optic nerve infarction in rhino-cerebral mucormycosis: a rare magnetic resonance imaging finding","volume":"6","author":"Ghuman","year":"2015","unstructured":"19. Ghuman MS, Kaur S, Bhandal SK, Ahluwalia A, Saggar K. Bilateral optic nerve infarction in rhino-cerebral mucormycosis: a rare magnetic resonance imaging finding. J Neurosci Rural Pract 2015;6:403-4.","journal-title":"J Neurosci Rural Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1148\/radiology.160.1.3715034","article-title":"Craniofacial mucormycosis: assessment with CT","volume":"160","author":"Gamba","year":"1986","unstructured":"20. Gamba JL, Woodruff WW, Djang WT, Yeates AE. Craniofacial mucormycosis: assessment with CT. Radiology 1986;160:207-2.","journal-title":"Radiology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1259\/imaging.20110001","article-title":"Head and neck imaging: sinonasal imaging","volume":"22","author":"Hussain","year":"2013","unstructured":"21. Hussain S, Woo EK, Conner SEJ. Head and neck imaging: sinonasal imaging. 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