{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:05:03Z","timestamp":1788411903437,"version":"build-2803163510"},"reference-count":8,"publisher":"Rambam Health Corporation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rambam Maimonides Med J"],"abstract":"<jats:p>Objective: Idiopathic eosinophilic vasculitis has been described in previous case series as a possible manifestation of hypereosinophilic syndrome (HES) in asthma-free patients. A rare disease, it can be classified as an eosinophilic-rich, necrotizing, systemic form of vasculitis that affects vessels of various sizes in these patients. This report shares our experience with the treatment of a patient with eosinophilic vasculitis.  Case Presentation: We present the case of a 45-year-old man who suffered from idiopathic HES manifesting as digital ulcers and peripheral ischemia of both the upper and lower limbs without the involvement of other systems. Diagnosis was made after excluding the primary and secondary causes of eosinophilia. The patient responded well to both corticosteroids and mepolizumab, an interleukin-5 inhibitor, as a corticosteroid-sparing therapy.  Conclusion: Our case of HES-associated vasculitis in an asthma-free patient supports previous reports describing this rare diagnosis of idiopathic eosinophilic vasculitis in recent years. We describe a good response to mepolizumab (interleukin-5 inhibitor) in our patient.<\/jats:p>","DOI":"10.5041\/rmmj.10498","type":"journal-article","created":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T11:00:51Z","timestamp":1682852451000},"page":"e0011","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic Eosinophilic Vasculitis: Case Presentation and Literature Review"],"prefix":"10.5041","volume":"14","author":[{"name":"Rheumatology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Broyde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Elkayam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Rheumatology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2983","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Lef\u00e8vre G, Leures A, Gibier JB, et al. \"Idiopathic eosinophilic vasculitis\": another side of hypereosinophilic syndrome? A comprehensive analysis of 117 cases in asthma free patients. J Allergy Clin Immunol Pract 2020;8:1329-40.e3.","DOI":"10.1016\/j.jaip.2019.12.011"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ajh.26352","article-title":"World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Shomali","year":"2022","unstructured":"2. Shomali W, Gotlib J. World Health Organization-defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management. Am J Hematol 2022;97:129-48.","journal-title":"Am J Hematol"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Ganeva M, Gancheva T, Lazarova R, et al. Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review. Int J Dermatol 2008;47;853-60.","DOI":"10.1111\/j.1365-4632.2008.03637.x"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1590\/S1806-37132009000600010","article-title":"Pulmonary eosinophilia","volume":"35","author":"LE","year":"2009","unstructured":"4. Campos LE, Pereira LF. Pulmonary eosinophilia. J Bras Pneumol 2009;35:561-73.","journal-title":"J Bras Pneumol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1007\/s10620-005-9011-2","article-title":"Eosinophilic gastroenteritis: a review","volume":"52","author":"M\u00e9ndez-S\u00e1nchez","year":"2007","unstructured":"5. M\u00e9ndez-S\u00e1nchez N, Ch\u00e1vez-Tapia NC, Vazquez-Elizondo G, Uribe M. Eosinophilic gastroenteritis: a review. Did Dis Sci 2007;52:2904-11.","journal-title":"Did Dis Sci"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/annrheumdis-2021-221794","article-title":"2022 American College of Rheumatology\/European Alliance of Associations for Rheumatology classification for eosinophilic granulomatosis with polyangiitis","volume":"81","author":"Grayson","year":"2022","unstructured":"6. Grayson PC, Ponte C, Suppiah R, et al. 2022 American College of Rheumatology\/European Alliance of Associations for Rheumatology classification for eosinophilic granulomatosis with polyangiitis. Ann Rheum Dis 2022;81:309-14.","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2421760","DOI":"10.1155\/2017\/2421760","article-title":"A rare case of digital ischemia and gangrene in ANCA-associated vasculitis with review of the literature","volume":"2017","author":"Lau","year":"2017","unstructured":"7. Lau RA, Bains R, Suraweera D, et al. A rare case of digital ischemia and gangrene in ANCA-associated vasculitis with review of the literature. Case Rep Rheumatol 2017;2017:2421760.","journal-title":"Case Rep Rheumatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5353575","DOI":"10.1155\/2021\/5353575","article-title":"Sensory-motor polyneuropathy and digital ischemia: a rare presentation of granulomatosis with polyangiitis","volume":"2021","author":"Wathurapatha","year":"2021","unstructured":"8. Wathurapatha W, Rathnamali BGA, Dissanayake U. Sensory-motor polyneuropathy and digital ischemia: a rare presentation of granulomatosis with polyangiitis. Case Rep Rheumatol 2021;2021:5353575.","journal-title":"Case Rep Rheumatol"}],"container-title":["Rambam Maimonides Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.rmmj.org.il\/userimages\/1592\/0\/PublishFiles\/1592Article.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:37:12Z","timestamp":1730723832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rmmj.org.il\/issues\/57\/articles\/1592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,30]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,4,30]]}},"URL":"https:\/\/doi.org\/10.5041\/rmmj.10498","relation":{},"ISSN":["2076-9172"],"issn-type":[{"value":"2076-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,30]]}}}