{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:44:24Z","timestamp":1791567864226,"version":"4.3.4"},"reference-count":30,"publisher":"Rambam Health Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rambam Maimonides Med J"],"abstract":"<jats:p>Objective: A single layer of tightly spaced cells, known as the endothelium, rests on the posterior side of the cornea. This endothelium regulates the stroma\u2019s relative dehydration, which is essential for corneal clarity. Cell therapy is an innovative method being used to repair various corneal abnormalities. Mesenchymal stem cells (MSCs) are now one of the most significant types of stem cells scientists have studied. This study aimed to evaluate the role of MSCs for corneal endothelial regeneration.  Methods: A systematic review was performed by searching for articles from reputable databases with many study-type references, including PubMed, Cochrane Library, Science Direct, and Google Scholar, up to January 2024. The resulting data were displayed using the 2020 PRISMA flowchart and evaluated using the PRISMA 2020 checklist. Most of the included studies were in vivo and used topical application and anterior chamber injection as the administration routes.  Results: Based on the findings of this review, MSCs increased corneal endothelial cell density, improved the defect area and corneal transparency, facilitated endothelial cell regeneration and wound healing, and decreased neovascularization and corneal pro-inflammatory cytokines as compared to controls.  Conclusion: Administration of MSCs into the anterior chamber could increase regeneration and proliferation of corneal endothelial tissue.<\/jats:p>","DOI":"10.5041\/rmmj.10531","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T06:55:12Z","timestamp":1730098512000},"page":"e0017","source":"Crossref","is-referenced-by-count":5,"title":["The Role of Mesenchymal Stem Cells for Corneal Endothelial Regeneration: A Systematic Review"],"prefix":"10.5041","volume":"15","author":[{"name":"Department of Ophthalmology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siska","family":"Siska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gede Eka","family":"Wiratnaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Orthopedics and Traumatology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Made","family":"Bakta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Made","family":"Jawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Pharmacology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Gde Raka","family":"Widiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"3Department of Internal Medicine, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putu","family":"Yuliawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Ophthalmology, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Made Ratna","family":"Saraswati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Internal Medicine, Faculty of Medicine, Udayana University, Denpasar, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heri","family":"Suroto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Orthopaedics and Traumatology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2983","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"100987","DOI":"10.1016\/j.preteyeres.2021.100987","article-title":"Approaches for corneal endothelium regenerative medicine","volume":"87","author":"Catal\u00e0","year":"2022","unstructured":"1. 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