{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T20:42:35Z","timestamp":1777840955182,"version":"3.51.4"},"reference-count":40,"publisher":"Rambam Health Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rambam Maimonides Med J"],"abstract":"<jats:p>IgG4-related disease (IgG4-RD) is a rare illness with inflammatory and fibrotic changes in affected organs such as pancreas, thyroid, salivary or lacrimal glands, and retroperitoneal space; rarely other organs may be involved. IgG4-related breast disease (IgG4-BD) is very rare and generally presents as a lump or mastitis. IgG4-BD as a presenting feature of IgG4-RD is extremely rare. Hence, this paper reviews the known (n=48) IgG-BD cases reported in the literature to date. The majority of cases were diagnosed on routine mammography or during assessment for other clinically significant features. The absence of a lump border, and especially the absence of calcifications on ultrasonography, mammography, or computed tomography, is typical for IgG4-BD. Characteristic IgG4-BD pathological findings were dense lymphoplasmacytic infiltration with stromal fibrosis, and more than 10% IgG4+ plasma cells\/high-power field (HPF); the mean percentage of IgG4+\/IgG+ plasma cells was 54.2%, and only one-third of the patients had all \u201cclassical\u201d signs of IgG4-BD including storiform fibrosis and obliterative phlebitis. Most of the cases had a benign course and responded to surgical excision with or without steroid therapy.<\/jats:p>","DOI":"10.5041\/rmmj.10532","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T06:55:12Z","timestamp":1730098512000},"page":"e0018","source":"Crossref","is-referenced-by-count":4,"title":["IgG4-related Breast Disease: Review of the Literature"],"prefix":"10.5041","volume":"15","author":[{"name":"Rheumatology Unit, Galilee Medical Center, Nahariya, Israel and The Azrieli Faculty of Medicine, BarIlan University, Safed, Israel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helana","family":"Jeries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Braun-Moscovici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Balbir-Gurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2983","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1007\/s00535-003-1175-y","article-title":"A new clinicopathological entity of IgG4-related autoimmune disease","volume":"38","author":"Kamisawa","year":"2003","unstructured":"1. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. 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