{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:03:31Z","timestamp":1789697011777,"version":"4.0.1"},"reference-count":40,"publisher":"XMLink","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00222390"],"award-info":[{"award-number":["RS-2023-00222390"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpis.org"],"crossmark-restriction":false},"short-container-title":["J Periodontal Implant Sci"],"DOI":"10.5051\/jpis.2504440222","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:29:08Z","timestamp":1789694948000},"update-policy":"https:\/\/doi.org\/10.5051\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic periodontitis induces cognitive decline in young adult mice"],"prefix":"10.5051","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8114-5004","authenticated-orcid":false,"given":"Kavitha","family":"Sajukumar","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chosun University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5248-9855","authenticated-orcid":false,"given":"Prabhakar","family":"Yadav","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-549X","authenticated-orcid":false,"given":"Sang-Joun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Chosun University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6626-6349","authenticated-orcid":false,"given":"Gum Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chosun University, Gwangju, Korea."},{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chosun University, Gwangju, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"Suppl 1","key":"10.5051\/jpis.2504440222_ref1","first-page":"S11","volume":"54","author":"Highfield","year":"2009","journal-title":"Aust Dent J"},{"key":"10.5051\/jpis.2504440222_ref2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontol 2000"},{"key":"10.5051\/jpis.2504440222_ref3","doi-asserted-by":"crossref","first-page":"709438","DOI":"10.3389\/fphys.2021.709438","volume":"12","author":"Mart\u00ednez-Garc\u00eda","year":"2021","journal-title":"Front Physiol"},{"key":"10.5051\/jpis.2504440222_ref4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/jcpe.13807","volume":"50","author":"Herrera","year":"2023","journal-title":"J Clin Periodontol"},{"key":"10.5051\/jpis.2504440222_ref5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jgs.13781","volume":"64","author":"Shin","year":"2016","journal-title":"J Am Geriatr Soc"},{"key":"10.5051\/jpis.2504440222_ref6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jcpe.13779","volume":"50","author":"Marruganti","year":"2023","journal-title":"J Clin Periodontol"},{"key":"10.5051\/jpis.2504440222_ref7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3233\/JAD-169006","volume":"54","author":"Cestari","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.5051\/jpis.2504440222_ref8","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/jcpe.13861","volume":"50","author":"Carballo","year":"2023","journal-title":"J Clin Periodontol"},{"key":"10.5051\/jpis.2504440222_ref9","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/jgs.15828","volume":"67","author":"Choi","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"10.5051\/jpis.2504440222_ref10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41432-023-00915-2","volume":"24","author":"Goyal","year":"2023","journal-title":"Evid Based Dent"},{"key":"10.5051\/jpis.2504440222_ref11","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci Adv"},{"key":"10.5051\/jpis.2504440222_ref12","first-page":"100547","volume":"5","author":"Shen","year":"2023","journal-title":"Innovation (Camb)"},{"key":"10.5051\/jpis.2504440222_ref13","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1111\/odi.14674","volume":"30","author":"Xie","year":"2024","journal-title":"Oral Dis"},{"key":"10.5051\/jpis.2504440222_ref14","doi-asserted-by":"crossref","first-page":"1563405","DOI":"10.1080\/20002297.2018.1563405","volume":"11","author":"Singhrao","year":"2019","journal-title":"J Oral Microbiol"},{"key":"10.5051\/jpis.2504440222_ref15","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1007\/s10072-021-05115-3","volume":"42","author":"Hategan","year":"2021","journal-title":"Neurol Sci"},{"key":"10.5051\/jpis.2504440222_ref16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/jcpe.13155","volume":"46","author":"Sung","year":"2019","journal-title":"J Clin Periodontol"},{"key":"10.5051\/jpis.2504440222_ref17","first-page":"605","volume":"66","author":"Rajendran","year":"2024","journal-title":"J Oral Biosci\/ JAOB, Jpn Assoc Oral Biol"},{"key":"10.5051\/jpis.2504440222_ref18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/jispcd.JISPCD_349_20","volume":"11","author":"Sharma","year":"2021","journal-title":"J Int Soc Prev Community Dent"},{"key":"10.5051\/jpis.2504440222_ref19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-016-0191-9","volume":"9","author":"Shoji","year":"2016","journal-title":"Mol Brain"},{"key":"10.5051\/jpis.2504440222_ref20","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.cub.2023.02.035","volume":"33","author":"Levy","year":"2023","journal-title":"Curr Biol"},{"key":"10.5051\/jpis.2504440222_ref21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/jre.12298","volume":"51","author":"Duan","year":"2016","journal-title":"J Periodontal Res"},{"key":"10.5051\/jpis.2504440222_ref22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jim.2013.05.002","volume":"394","author":"Abe","year":"2013","journal-title":"J Immunol Methods"},{"key":"10.5051\/jpis.2504440222_ref23","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1523\/JNEUROSCI.2010-13.2013","volume":"33","author":"Trotter","year":"2013","journal-title":"J Neurosci"},{"key":"10.5051\/jpis.2504440222_ref24","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.5051\/jpis.2504440222_ref25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.5051\/jpis.2504440222_ref26","doi-asserted-by":"crossref","first-page":"1099017","DOI":"10.3389\/fimmu.2023.1099017","volume":"14","author":"Siddiqui","year":"2023","journal-title":"Front Immunol"},{"key":"10.5051\/jpis.2504440222_ref27","doi-asserted-by":"crossref","first-page":"100969","DOI":"10.1016\/j.bbih.2025.100969","volume":"44","author":"Jimenez-Harrison","year":"2025","journal-title":"Brain Behav Immun Health"},{"key":"10.5051\/jpis.2504440222_ref28","doi-asserted-by":"crossref","first-page":"9617","DOI":"10.1523\/JNEUROSCI.1202-21.2021","volume":"41","author":"Wang","year":"2021","journal-title":"J Neurosci"},{"key":"10.5051\/jpis.2504440222_ref29","doi-asserted-by":"crossref","first-page":"527543","DOI":"10.3389\/fnmol.2020.527543","volume":"13","author":"Cinalli","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"10.5051\/jpis.2504440222_ref30","doi-asserted-by":"crossref","first-page":"1358179","DOI":"10.3389\/fmicb.2024.1358179","volume":"15","author":"Li","year":"2024","journal-title":"Front Microbiol"},{"key":"10.5051\/jpis.2504440222_ref31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"10.5051\/jpis.2504440222_ref32","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41380-023-02386-4","volume":"29","author":"Chalmers","year":"2024","journal-title":"Mol Psychiatry"},{"key":"10.5051\/jpis.2504440222_ref33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nn1849","volume":"10","author":"Jourdain","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.5051\/jpis.2504440222_ref34","doi-asserted-by":"crossref","first-page":"1305790","DOI":"10.3389\/fnagi.2023.1305790","volume":"15","author":"Tan","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"10.5051\/jpis.2504440222_ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.01.017","volume":"58","author":"Chesnokova","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.5051\/jpis.2504440222_ref36","doi-asserted-by":"crossref","first-page":"e13005","DOI":"10.1111\/bpa.13005","volume":"31","author":"Yeung","year":"2021","journal-title":"Brain Pathol"},{"key":"10.5051\/jpis.2504440222_ref37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-019-0068-8","volume":"12","author":"Cheng","year":"2020","journal-title":"Int J Oral Sci"},{"key":"10.5051\/jpis.2504440222_ref38","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1038\/s41467-019-10910-w","volume":"10","author":"Salpietro","year":"2019","journal-title":"Nat Commun"},{"key":"10.5051\/jpis.2504440222_ref39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.conb.2012.01.007","volume":"22","author":"Hunt","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"10.5051\/jpis.2504440222_ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"}],"container-title":["Journal of Periodontal & Implant Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jpis.org\/pdf\/10.5051\/jpis.2504440222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpis.org\/DOIx.php?id=10.5051\/jpis.2504440222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpis.org\/DOIx.php?id=10.5051\/jpis.2504440222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:29:18Z","timestamp":1789694958000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpis.org\/DOIx.php?id=10.5051\/jpis.2504440222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"URL":"https:\/\/doi.org\/10.5051\/jpis.2504440222","relation":{},"ISSN":["2093-2278","2093-2286"],"issn-type":[{"value":"2093-2278","type":"print"},{"value":"2093-2286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2025-10-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2026. Korean Academy of Periodontology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/).","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e36"}}