{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T18:10:41Z","timestamp":1683137441568},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Disaster Med"],"abstract":"<jats:p>Objective: To determine if there were significant differences among humerus intraosseous (HIO), sternal intraosseous (SIO), and intravenous (IV) administration of 500 mL Hextend in hemodynamics or administration time in a hypovolemic swine model.Setting: Vivarium.Subjects: Yorkshire swine; sample size was based on a large effect size of 0.5, an \u03b1 of 0.05, and a power of 80 percent Swine were randomly assigned to one of four groups: HIO (n = 9), SIO (n = 9), IV (n = 9), and control (n = 9).Intervention: Swine were exsanguinated 30 percent of their blood volume. Hextend (500 mL) was administered by either the HIO, SIO, or IV route; the control group received none.Main Outcome: Time of administration of Hextend; systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and stroke volume (SV) data were collected every 2 minutes and compared by group over 8 minutes.Results: A repeated analysis of variance found that there were no significant differences in SBP, DBP, MAP, HR, CO, and SV among HIO, SIO, and IV groups over 8 minutes (p &gt; 0.05). An analyses of variance determined that there was no significant difference between groups relative to time of administration (p = 0.521).Conclusion: When IV access is difficult, both HIO and SIO are effective techniques for rapid vascular access and the administration of Hextend for patients in hypovolemic shock.<\/jats:p>","DOI":"10.5055\/ajdm.2016.0238","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T17:01:10Z","timestamp":1487782870000},"page":"183-192","source":"Crossref","is-referenced-by-count":1,"title":["Effects of intravenous, sternal, and humerus intraosseous administration of Hextend on time of administration and hemodynamics in a hypovolemic swine model"],"prefix":"10.5055","volume":"11","author":[{"given":"Dawn","family":"Blouin, BS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Gegel, DNAP, CRNA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Johnson, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose C.","family":"Garcia-Blanco, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3008","published-online":{"date-parts":[[2016,7,1]]},"container-title":["American Journal of Disaster Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.wmpllc.org\/ojs\/index.php\/ajdm\/article\/download\/452\/420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wmpllc.org\/ojs\/index.php\/ajdm\/article\/download\/452\/420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T17:45:22Z","timestamp":1683135922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wmpllc.org\/ojs\/index.php\/ajdm\/article\/view\/452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.5055\/ajdm.2016.0238","relation":{},"ISSN":["1932-149X","1932-149X"],"issn-type":[{"value":"1932-149X","type":"electronic"},{"value":"1932-149X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7,1]]}}}