{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:18:58Z","timestamp":1791357538734,"version":"4.3.1"},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objectives: To evaluate the effectiveness of transitioning patients from methadone to buprenorphine\/naloxone (BUP\/NLX) using morphine milligram equivalent (MME) dosing, with a focus on treatment adherence, withdrawal management, and therapeutic response, as illustrated through two patient case studies.\r\nMethods: Two participants (male, 33 years; female 42 years) were treated between June 2023 to January 2024 for opioid use disorder, undergoing BUP\/NLX induction from methadone in an opioid treatment program. MME low-dose initiations were utilized for dosage conversion. Data collected included patient demographics, vital signs, Clinical Opiate Withdrawal Scale assessment, MME low-dose initiation calculations, adverse events, treatment adherence, and outcomes.\r\nResults: MME dosing was based on initial methadone dosage and standard MME conversion ratios. Case 1: Sublingual BUP\/NLX was started at 0.5 mg, increased to 0.5 mg twice daily by day 3, and titrated until day 17; methadone (24 mg) was tapered off by day 17. Case 2: A similar initiation and tapering process was followed; methadone (11 mg) was discontinued by day 12. Both cases achieved stabilization on BUP\/NLX without severe adverse events or precipitated withdrawal symptoms.\r\nConclusions: MME low-dose initiations appear to be a feasible and safe method for BUP\/NLX induction. Further research involving patients on higher methadone doses and larger sample sizes, along prospective designs, is necessary to validate these findings and explore the long-term effectiveness and safety of MME-guided induction protocols across various clinical settings.<\/jats:p>","DOI":"10.5055\/jom.0923","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:00:36Z","timestamp":1760529636000},"page":"461-466","source":"Crossref","is-referenced-by-count":1,"title":["Navigating treatment transitions: Enhancing outpatient recovery with morphine milligram equivalent (MME) dosing in methadone to buprenorphine transition\u2014Case reports"],"prefix":"10.5055","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-8272","authenticated-orcid":false,"given":"Wali","family":"Yousufzai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roald","family":"Credo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Baronia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapila","family":"Marambage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorvanshi","family":"Alag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3008","published-online":{"date-parts":[[2025,10,1]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/3921\/4203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/3921\/4203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:00:37Z","timestamp":1760529637000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/3921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,14]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.0923","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}