{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:57:36Z","timestamp":1771977456759,"version":"3.50.1"},"reference-count":62,"publisher":"Weston Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objective: The objectives were to examine changes in kinesiophobia, pain self-efficacy, and knowledge of the neurophysiology of pain. We hypothesized that implementing an adapted-pain neuroscience education (a-PNE) curriculum, as a single intervention, for patients who experience chronic musculoskeletal pain and concurrent opioid dependence, would demonstrate positive change in kinesiophobia and self-efficacy regarding pain management, which may translate to improvements in functional ability.\r\nDesign: This study used a pretest\u2013post-test, quasi-experimental design.\r\nSetting: A formal opioid management program (OMP) within a clinic associated with the University of Kentucky.\r\nParticipants: Patients actively participating in the OMP.\r\nInterventions: Pain neuroscience education.\r\nMain outcome measures: The Tampa Scale for Kinesiophobia-11, the Pain Self-Efficacy Questionnaire (PSEQ), and the Neurophysiology of Pain Questionnaire (NPQ) were utilized during this study. Subjects completed each questionnaire at three time points: preintervention, post-intervention, and 90 days post-intervention. \r\nResults: No significant interactions between groups and the three time points were found. The a-PNE group significantly improved their knowledge between pre- and post-intervention on the NPQ and PSEQ according to paired-samples t-tests. The a-PNE group scored significantly higher at post-intervention and 90-day post-intervention than the general health education control group on the NPQ according to independent-samples t-tests.\r\nConclusion: An a-PNE curriculum may be beneficial in assisting patients to understand the neurophysiology behind their pain experience. Furthermore, positive changes were noted in pain self-efficacy. The results also indicate that an a-PNE curriculum intervention was acceptable in terms of approach and understandability for the participating patients.<\/jats:p>","DOI":"10.5055\/jom.0974","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:02:05Z","timestamp":1771974125000},"page":"111-121","source":"Crossref","is-referenced-by-count":0,"title":["Pain neuroscience education intervention for patients who experience chronic musculoskeletal pain with concurrent opioid dependence: A pilot study"],"prefix":"10.5055","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-2960","authenticated-orcid":false,"given":"Nicole D.","family":"Windsor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3008","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"99922","doi-asserted-by":"crossref","unstructured":"Louw A, Zimney K, Puentedura EJ, et al.: The efficacy of pain neuroscience education on musculoskeletal pain: A systematic review of the literature. 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