{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:36:17Z","timestamp":1761676577606},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Background: Chronic noncancer pain is often undertreated.Aims: To assess the efficacy of fentanyl transdermal therapeutic system (TTS) associated with oral transmucosal fentanyl citrate (OTFC) for breakthrough pain in patients with chronic noncancer pain.Methods: A total of 215 patients with chronic (\u22656 months), severe (VAS \u2265 8) noncancer pain participated in a 6-month prospective study. The starting dose of 12 \u03bcg\/h fentanyl TTS was titrated in 25 \u03bcg\/h increments to a visual analog scale (VAS) score \u2264 4. OTFC was administered as single-unit doses of 400 \u03bcg.Results: The mean (SD) VAS score decreased from 9.86 (0.35) at baseline to 2.05 (0.96) at 6 months. The percentage of patients with poor quality of sleep decreased from 99 percent at baseline to 2.8 percent at the end of the study. The percentage of patients with inadequate pain control decreased from 16.2 percent at month 1 to 2.3 percent at month 6. Pain control was achieved with the 50 \u03bcg\/h dose in 48 percent of patients, the 75 \u03bcg\/h dose in 18 percent, and the 100 \u03bcg\/h dose in 5 percent (only two patients required &gt;100 \u03bcg\/h). The daily use of single-unit doses of OTFC decreased from 4.64 at month 1 to 2.62 at month 6. Headache, nausea\/vomiting, constipation, and somnolence of mild or moderate intensity were the most common side effects. Treatment was discontinued because of nausea\/vomiting in seven patients, somnolence in three, and dermatitis in two.Conclusions: Fentanyl TTS associated with OTFC for breakthrough pain is a feasible and effective strategy in opioid na\u00efve patients with severe chronic nonmalignant pain.<\/jats:p>","DOI":"10.5055\/jom.2008.0016","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T16:25:29Z","timestamp":1517588729000},"page":"111-115","source":"Crossref","is-referenced-by-count":10,"title":["Association of transdermal fentanyl and oral transmucosal fentanyl citrate in the treatment of opioid na\u00efve patients with severe chronic noncancer pain"],"prefix":"10.5055","volume":"4","author":[{"given":"Francisco","family":"Collado, MD, PhD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Torres, MD, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3008","published-online":{"date-parts":[[2018,1,30]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/980\/990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/980\/990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T15:27:47Z","timestamp":1683646067000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2008.0016","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,30]]}}}