{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:56:05Z","timestamp":1791251765414,"version":"4.1.0"},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Background: \u03bc-Opiate receptor agonism has been associated with weight gain, whereas \u03bc-antagonists have been associated with weight neutrality, or even weight loss.Aim: This study examined the course of weight changes in opiate-dependent patients over the first 6 months of treatment in methadone (agonist) versus naltrexone (antagonist) maintenance.Design: A retrospective chart review was conducted on 36 opiate-dependent patients maintained on methadone (n = 16) or naltrexone (n = 20). Outcome measures and analyses: The primary outcome measure was change in body weight from baseline to 3 months and 6 months into treatment. Analysis of variance was used to compare mean weights between the methadone- and naltrexone-maintained patients. Secondarily, mean percent weight changes from baseline to 3 months and from baseline to 6 months into treatment were compared using Student\u2019s t-test.Results: There was no difference between weight at baseline, 3 months, or 6 months into treatment between the two treatment groups. Furthermore, there was also no difference between the two groups regarding percent weight change from baseline to 3 months or baseline to 6 months. At 3 months, n = 16 methadone patients had a mean weight increase of 1.86 percent (standard deviation [SD] = 7.22 percent) when compared with n = 20 Behavioral Naltrexone Therapy (BNT) patients with an increase of 4.63 percent (SD = 6.49 percent). At 6 months, n = 16 methadone patients had a mean weight increase relative to baseline of 3.67 percent (SD = 9.52 percent) when compared with n = 20 BNT patients, who demonstrated a mean increase of 6.69 percent (SD = 7.56 percent). No association was found between baseline weight, defined as \u201clow\u201d or \u201chigh\u201d relative to group medians, and percent gain within and between treatment groups.Conclusions: This study did not detect a statistically different course of weight gain between methadone and naltrexone maintenance treatment for opiate-dependent patients.<\/jats:p>","DOI":"10.5055\/jom.2011.0048","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T17:32:41Z","timestamp":1302024761000},"page":"47-53","source":"Crossref","is-referenced-by-count":22,"title":["Course of weight change during naltrexone versus methadone maintenance for opioid-dependent patients"],"prefix":"10.5055","volume":"7","author":[{"given":"David J.","family":"Mysels, MD, MBA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne K.","family":"Vosburg, PhD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Benga, MD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances R.","family":"Levin, MD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Sullivan, MD, PhD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3008","published-online":{"date-parts":[[2018,1,15]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/851\/861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/851\/861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:09:01Z","timestamp":1682968141000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,1,1]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2011.0048","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,15]]}}}