{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:06:55Z","timestamp":1784030815281,"version":"3.55.0"},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objective: To evaluate the efficacy and safety of an encapsulated, highly viscous formulation of extended-release oxycodone designed to resist common physical manipulation and chemical challenges (Remoxy\u00ae; King Pharmaceuticals, Inc., Bristol, TN, which was acquired by Pfizer Inc. in March 2011).Design: An enriched enrollment randomized withdrawal trial design was used whereby patients entered a double-blind, multicenter, placebo-controlled trial after completing an open-label titration phase.Setting: Sixty-one US clinics.Patients: All patients (40-75 years) had experienced moderate to severe chronic osteoarthritic pain in the hip or knee for3 months.Interventions: During 2 weeks of open-label treatment (N \u2265 558), patients were titrated from Remoxy 5 mg twice daily (bid) to 20 mg bid. Patients who tolerated the drug were randomly assigned to Remoxy or placebo bid for 12 weeks. Dose titration was permitted during weeks 1-4 (range, 10-80 mg\/d) and fixed thereafter.Main outcome measures: The area under the curve (AUC) for change in pain intensity (PI) scores from prerandomization to the end of the 12-week period was the primary endpoint. Patient assessment of quality of analgesia, global assessment of study medication, quality of life, and safety were also evaluated.Results: The mean AUC for change in PI score was significantly greater for Remoxy than for placebo (p = 0.007). Patients receiving Remoxy reported significantly better scores on quality of analgesia (p = 0.004) and global assessment of study medication (p = 0.007) when compared with patients receiving placebo. Remoxy had a safety profile consistent with other opioids.Conclusions: Remoxy significantly improved analgesia among patients with moderate to severe chronic osteoarthritic pain with an adverse event profile similar to other opioids.<\/jats:p>","DOI":"10.5055\/jom.2011.0062","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T16:09:05Z","timestamp":1311696545000},"page":"193-202","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy and safety of an extended-release oxycodone (Remoxy\u00ae) formulation in patients with moderate to severe osteoarthritic pain"],"prefix":"10.5055","volume":"7","author":[{"given":"Nadav","family":"Friedmann, PhD, MD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Klutzaritz, BS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Webster, MD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3008","published-online":{"date-parts":[[2018,1,15]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/830\/840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/830\/840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:45:23Z","timestamp":1682970323000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2011.0062","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,15]]}}}