{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:30:11Z","timestamp":1769311811330,"version":"3.49.0"},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objective: Hyperalgesia has been observed in active opioid addicts (OAs). The aim of this study was to explore whether opioid-induced hyperalgesia (OIH) is a reversible phenomenon. Design: Observational study. Participants: The study included the following three groups of male subjects: 1) active addicts on heroin or methadone (OAs, n = 50); 2) former opioid addicts with at least 5 months of abstinence from drug use (FOAs, n = 43); and 3) drug na\u00efve controls (C, n = 50). Interventions: All subjects were exposed to the cold pressor test (1\u00b0C). Main outcome measures: Cold pain threshold (latency to pain onset, seconds) and cold pain tolerance (latency to pain intolerability, seconds). Results: Mean \u00b1 standard deviation (SD) pain thresholds were 10.8 \u00b1 7.7, 6.9 \u00b1 3.9, and 6.8 \u00b1 3.5 seconds for the OAs, FOAs, and C groups, respectively (analysis of variance [ANOVA], p _ 0.002, 95% CI = 7.5-9.2). Mean \u00b1 SD pain tolerance levels were 30 \u00b1 36.2, 64 \u00b1 58.1, and 56.4 \u00b1 51.4 seconds for the OAs, FOAs, and C groups, respectively (ANOVA, p &lt; 0.001, 95% CI = 43-60.4). Post hoc analyses revealed significant changes between the OAs and the other two groups for both variables. Conclusions: It is suggested that altered pain perception in OAs is a reversible phenomenon that may require a long period of abstinence to reset, rather than being an individual long-term stable trait. Keywords: cold pressor test, former opioid addicts, opioid addicts, hyperalgesia DOI:10.5055\/jom.2012.0134<\/jats:p>","DOI":"10.5055\/jom.2012.0134","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T04:39:02Z","timestamp":1357706342000},"page":"343-349","source":"Crossref","is-referenced-by-count":16,"title":["Is opioid-induced hyperalgesia reversible? A study on active and former opioid addicts and drug na\u00efve controls"],"prefix":"10.5055","volume":"8","author":[{"given":"Roi","family":"Treister, PhD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elon","family":"Eisenberg, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Lawental, DSW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Pud, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3008","published-online":{"date-parts":[[2012,11,1]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/19\/1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/19\/1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:57:23Z","timestamp":1749578243000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,5,4]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2012.0134","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,1]]}}}