{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:26:37Z","timestamp":1787261197249,"version":"build-2736575974"},"reference-count":38,"publisher":"Weston Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objective: To determine what, if any, public health and societal impacts are associated specifically with injection of prescription opioids. Design: Cross-sectional observational study. Setting: Five hundred forty treatment facilities in 35 states across the United States performing Addiction Severity Index-Multimedia Version (ASI-MV) assessments. Participants: Adult patients (29,459) who reported past 30-day abuse of any prescription opioid on the ASI-MV assessment between January 2007 and January 2011. Main outcome measures: The public health indicators selected for this study were liver disease, HIV\/AIDS status, recent visit to an emergency room, treatment for pain, treatment for overdosing, homelessness, residence with alcohol\/substance abuser, and unemployment. Results: Prescription opioid injection was significantly associated with health problems, psychosocial problems, and utilization of medical services. Conclusions: This study demonstrates an approach to measure the potential impact of injecting prescription opioids on public health indicators. Findings indicate a positive association between injection of prescription opioids and public health indicators suggesting a need for prescription opioid formulations that may inhibit injection of these medications. Keywords: prescription drug injection, public health, correlates DOI:10.5055\/jom.2013.0142<\/jats:p>","DOI":"10.5055\/jom.2013.0142","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T11:28:55Z","timestamp":1362742135000},"page":"5-17","source":"Crossref","is-referenced-by-count":20,"title":["Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment"],"prefix":"10.5055","volume":"9","author":[{"given":"Ryan A.","family":"Black, PhD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee J.","family":"Trudeau, PhD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Cassidy, MPH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon H.","family":"Budman, PhD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Butler, PhD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3008","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Chou R, Fanciullo GJ, Fine PG, et al.: Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009; 10: 113-130.","DOI":"10.1016\/j.jpain.2008.10.008"},{"key":"2","unstructured":"Institute of Medicine of The national Academies: Relieving Pain in America, A blueprint for Transforming Prevention, Care, Education, and Research. 2011. Report Brief, June. Available at"},{"key":"3","unstructured":"www.iom.edu\/relievingpain. Accessed June 29, 2011."},{"key":"4","doi-asserted-by":"crossref","unstructured":"Brennan F, Carr DB, Cousins M, et al.: Pain management: A fundamental human right. Anesth Analg. 2007; 105: 205-221.","DOI":"10.1213\/01.ane.0000268145.52345.55"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Reidenberg MM, Willis O: Prosecution of physicians for prescribing opioids to patients. Clin Pharmacol Ther. 2007; 81(6):903-906.","DOI":"10.1038\/sj.clpt.6100127"},{"key":"6","unstructured":"Substance Abuse and Mental Health Services Administration, Office of Applied Studies: Detailed Tables, 2009 National Survey on Drug Use & Health. 2010. Available at http:\/\/oas.samhsa."},{"key":"7","unstructured":"gov\/WebOnly.htm#NSDUHtabs. Accessed September 2011."},{"key":"8","doi-asserted-by":"crossref","unstructured":"Katz N: Abuse-deterrent opioid formulations: Are they a pipe dream? Curr Rheumatol Rep. 2008; 10(1): 11-18.","DOI":"10.1007\/s11926-008-0003-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Raffa RB, Pergolizzi JV Jr: Opioid formulations designed to resist\/deter abuse. Drugs. 2010; 70(13): 1657-1675.","DOI":"10.2165\/11537940-000000000-00000"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Compton WM, Volkow ND: Abuse of prescription drugs and the risk of addiction. Drug Alcohol Depend. 2006; 83(suppl 1):S4-S7.","DOI":"10.1016\/j.drugalcdep.2005.10.020"},{"key":"11","unstructured":"National Institute on Drug Abuse: Prescription and over-thecounter medications (NIDA InfoFacts). 2009. Available at http:\/\/www.nida.nih.gov\/PDF\/Infofacts\/PainMed09.pdf. Accessed December 2012."},{"key":"12","doi-asserted-by":"crossref","unstructured":"Katz N, Dart RC, Bailey E, et al.: Tampering with prescription opioids: Nature and extent of the problem, health consequences, and solutions. Am J Drug Alcohol Abuse. 2011; 37(4): 205-217.","DOI":"10.3109\/00952990.2011.569623"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Sherman SG, Cheng Y, Kral AH, et al.: Prevalence and correlates of opiate overdose among young injection drug users in a large U.S. city. Drug Alcohol Depend. 2007; 88(2-3): 182-187.","DOI":"10.1016\/j.drugalcdep.2006.10.006"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Milloy MJ, Kerr T, Mathias R, et al.: Non-fatal overdose among a cohort of active injection drug users recruited from a supervised injection facility. Am J Drug Alcohol Abuse. 2008; 34(4): 499-509.","DOI":"10.1080\/00952990802122457"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Stoov\u00e9 MA, Dietze PM, Aitken CK, et al.: Mortality among injecting drug users in Melbourne: A 16-year follow-up of the Victorian Injecting Cohort Study (VICS). Drug Alcohol Depend.2008; 96(3): 281-285.","DOI":"10.1016\/j.drugalcdep.2008.03.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Vlahov D, Wang C, Ompad D, et al.: Collaborative Injection Drug User Study. Mortality risk among recent-onset injection drug users in five U.S. Cities. Subst Use Misuse. 2008; 43(3-4): 413-428.","DOI":"10.1080\/10826080701203013"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Disney E, Kidorf M, Kolodner K, et al.: Psychiatric comorbidity is associated with drug use and HIV risk in syringe exchange participants. J Nerv Ment Dis. 2006; 194: 577-583.","DOI":"10.1097\/01.nmd.0000230396.17230.28"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Aceijas C, Rhodes T: Global estimates of prevalence of HCV infection among injecting drug users. Int J Drug Policy. 2007; 18(5): 352-358.","DOI":"10.1016\/j.drugpo.2007.04.004"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Neaigus A, Miller M, Friedman SR, et al.: Potential risk factors for the transition to injecting among non-injecting heroin users: A comparison of former injectors and never injectors. Addiction. 2001; 96: 847-860.","DOI":"10.1046\/j.1360-0443.2001.9668476.x"},{"key":"20","unstructured":"Green TC, Butler SF: A latent class analysis of Rx opioid abuse in the National Addictions Vigilance Intervention & Prevention Program (NAVIPPRO\u2122). San Juan, Puerto Rico: College on Drug Dependence, 2008."},{"key":"21","doi-asserted-by":"crossref","unstructured":"Green TC, Black R, Grimes Serrano JM, et al.: Typologies of prescription opioid use in a large sample of adults assessed for substance abuse treatment. PLoS One. 2011; 6(11): e27244.","DOI":"10.1371\/journal.pone.0027244"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Marshall BD, Fairbairn N, Li K, et al.: Physical violence among a prospective cohort of injection drug users: A genderfocused approach. Drug Alcohol Depend. 2008; 97(3): 237-246.","DOI":"10.1016\/j.drugalcdep.2008.03.028"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Young AM, Havens JR, Leukefeld CG, et al.: Route of administration for illicit prescription opioids: A comparison of rural and urban drug users. Harm Reduct J. 2010; 7: 24.","DOI":"10.1186\/1477-7517-7-24"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Butler SF, Black R, Grimes Serrano JM, et al.: Characteristics of prescription opioid abusers in treatment: Opioid use history, age, use patterns, and functional severity. J Opioid Manag. 2010; 6(4): 230-252.","DOI":"10.5055\/jom.2010.0022"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Butler SF, Budman SH, Licari A, et al.: National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO\u2122): A real-time, product-specific, public health surveillance system for monitoring Rx drug abuse. Pharmacoepidemiol Drug Saf. 2008; 17(12): 1142-1154.","DOI":"10.1002\/pds.1659"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Hendricks VM, Kaplan CD, VanLimbeek J, et al.: The Addiction Severity Index: Reliability and validity in a Dutch addict population. J Subst Abuse Treat. 1989; 6: 133-141.","DOI":"10.1016\/0740-5472(89)90041-X"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Kosten TR, Rounsaville BJ, Kleber HD, et al.: Concurrent validity of the Addiction Severity Index. J Nerv Ment Dis. 1983; 171(10): 606-610.","DOI":"10.1097\/00005053-198310000-00003"},{"key":"28","doi-asserted-by":"crossref","unstructured":"McLellan AT, Luborsky L, Woody GE, et al.: An improved diagnostic evaluation instrument for substance abuse patients. J Nerv Ment Dis. 1980; 168: 26-33.","DOI":"10.1097\/00005053-198001000-00006"},{"key":"29","doi-asserted-by":"crossref","unstructured":"McLellan AT, Kushner H, Metzger D, et al.: The fifth edition of the Addiction Severity Index. J Subst Abuse Treat. 1992; 9(3): 199-213.","DOI":"10.1016\/0740-5472(92)90062-S"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Butler SF, Budman SH, Goldman RJ, et al.: Initial validation of a computer-administered Addiction Severity Index: The ASIMV. Psychol Addict Behav. 2001; 15(1): 4-12.","DOI":"10.1037\/\/0893-164X.15.1.4"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Butler SF, Redondo JP, Fernandez KC, et al.: Validation of the Spanish Addiction Severity Index Multimedia Version (SASI-MV). Drug Alcohol Depend. 2009; 99(1-3): 18-27.","DOI":"10.1016\/j.drugalcdep.2008.06.012"},{"key":"32","unstructured":"McGahan PL, Griffith JA, Parente R, et al.: Composite Scores from the Addiction Severity Index. Philadelphia, PA: Department of Veterans Affairs Medical Center, 1986."},{"key":"33","doi-asserted-by":"crossref","unstructured":"Katz NP, Adams EH, Chilcoat H, et al.: Challenges in the development of prescription opioid abuse-deterrent formulations.Clin J Pain. 2007; 8: 648-660.","DOI":"10.1097\/AJP.0b013e318125c5e8"},{"key":"34","unstructured":"Kleinbaum DG, Kupper LL, Nizam A, and et al.: Applied Regression Analysis and Other Multivariable Methods. 4th ed. Pacific Grove: Duxbury Press\/Cengage Learning, 2008."},{"key":"35","doi-asserted-by":"crossref","unstructured":"Neaigus A, Gyarmathy VA, Miller M, et al.: Injecting and sexual risk correlates of HBV and HCV seroprevalence among new drug injectors. Drug Alcohol Depend. 2007; 89(2-3): 234-243.","DOI":"10.1016\/j.drugalcdep.2007.01.003"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Hall AJ, Logan JE, Toblin RL, et al.: Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA. 2008; 300(22): 2613-2620.","DOI":"10.1001\/jama.2008.802"},{"key":"37","unstructured":"US FDA: FDA Approves New Formulation for Oxycontin. April 5, 2010. 2010. Available at www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm207480.htm. Accessed April 5, 2010."},{"key":"38","unstructured":"Pain Therapeutics Inc.: FDA Complete Response Letter Received for REMOXY. June 24, 2011. Available at http:\/\/www.paintrials.com\/publications\/PR24June2011CRL.pdf. Accessed June 24, 2011."}],"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/28\/10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/28\/10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:06:20Z","timestamp":1787259980000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2013.0142","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}