{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:29:40Z","timestamp":1773682180189,"version":"3.50.1"},"reference-count":0,"publisher":"Weston Medical Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Opioid Management"],"abstract":"<jats:p>Objective: To determine the independent and combined effects of pain and opioids on the activation of an early marker of inflammation, nuclear factor-\u03baB (NF-\u03baB).Design: NF-\u03baB activation was compared within-subjects following four randomly ordered experimental sessions of opioid-only (intravenous fentanyl 1 \u03bcg\/kg), pain-only (cold-pressor), opioid + pain, and a resting condition.Setting: University General Clinical Research Center.Participants: Twenty-one (11 female) healthy controls.Interventions: Following exposure to treatment (fentanyl administration and\/or cold-pressor pain), blood samples for NF-kB analysis were obtained.Main outcome measures: Intracellular levels of activated NF-\u03baB, in unstimulated and stimulated peripheral blood mononuclear cells at 15 and 30 minutes.Results: Neither pain nor opioid administration alone effected NF-\u03baB levels in cell populations; however, the combination of treatments induced significant increases of NF-\u03baB in stimulated peripheral blood mononuclear cell, lymphocytes, and monocytes.Conclusions: The combination of acute pain with opioids, as occurs in clinical situations, activates a key transcription factor involved in proinflammatory responses.<\/jats:p>","DOI":"10.5055\/jom.2015.0261","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T14:19:02Z","timestamp":1434377942000},"page":"115-125","source":"Crossref","is-referenced-by-count":5,"title":["Opioid treatment of experimental pain activates nuclear factor-\u03baB"],"prefix":"10.5055","volume":"11","author":[{"given":"Peggy","family":"Compton, RN, PhD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Griffis, CRNA, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Crabb Breen, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Torrington, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Sadakane, BS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eshetu","family":"Tefera, MS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Irwin, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3008","published-online":{"date-parts":[[2015,3,1]]},"container-title":["Journal of Opioid Management"],"original-title":[],"link":[{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/166\/142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/download\/166\/142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:48:48Z","timestamp":1682970528000},"score":1,"resource":{"primary":{"URL":"https:\/\/wmpllc.org\/ojs\/index.php\/jom\/article\/view\/166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.5055\/jom.2015.0261","relation":{},"ISSN":["1551-7489","1551-7489"],"issn-type":[{"value":"1551-7489","type":"electronic"},{"value":"1551-7489","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}