{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:18:51Z","timestamp":1792606731109,"version":"4.5.0"},"reference-count":116,"publisher":"The Korean Society of Neurogastroenterology and Motility","issue":"3","content-domain":{"domain":["www.jnmjournal.org"],"crossmark-restriction":true},"short-container-title":["J Neurogastroenterol Motil"],"published-print":{"date-parts":[[2018,7,30]]},"DOI":"10.5056\/jnm18029","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T04:31:09Z","timestamp":1525840269000},"page":"334-344","update-policy":"https:\/\/doi.org\/10.5056\/crossmark_policy","source":"Crossref","is-referenced-by-count":214,"title":["Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases"],"prefix":"10.5056","volume":"24","author":[{"given":"Tadayuki","family":"Oshima","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2998","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100102"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000200917"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"ref4","unstructured":"Ashida, K (2014). Notes on features and uses of medications used for PPI-resistant GERD, drugs under development and future prospects. Jpn J Med Pharm Sci. <em>71<\/em>, 591-596."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000200992"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199911000-00016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.05.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600615781"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04064.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.4.460.32128"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.20.153"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02079.x"},{"key":"ref13","unstructured":"Johnson, DA, and Katz, PO (2008). Nocturnal gastroesophageal reflux disease: issues, implications, and management strategies. Rev Gastroenterol Disord. <em>8<\/em>, 98-108."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0149-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0345-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02513.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03191.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.554429"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802693883"},{"key":"ref20","unstructured":"Wittbrodt, ET, Baum, C, and Peura, DA (2009). Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis. Clin Exp Gastroenterol. <em>2<\/em>, 117-128."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1986.tb09466.x"},{"key":"ref22","unstructured":"Wurst, W, and Hartmann, M (1996). Current status of acid pump antagonists (reversible PPIs). Yale J Biol Med. <em>69<\/em>, 233-243."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308320802"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.05.026"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2006.05.014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.120428"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.08.014"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01544.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06408.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14148"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(17)31747-X"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.06.020"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244202"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1177\/1087057111421004"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1021\/jm300318t"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.185314"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.02.009"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13414"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.08.001"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4100-y"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.170274"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02889.x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0326-7"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17745776"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.18"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13121"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.1.25"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13325"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13331"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0488-6"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00418.x"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.179556"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13588"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12452"},{"key":"ref55","unstructured":"Sachs, G, Meyer-Rosberg, K, Scott, DR, and Melchers, K (1996). Acid, protons and Helicobacter pylori. Yale J Biol Med. <em>69<\/em>, 301-316."},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00508.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0731-8"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14130"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4385161"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12456"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4305-0"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Noda, H, Noguchi, S, and Yoshimine, T (2016). A novel potassium-competitive acid blocker improves the efficacy of clarithromycin-containing 7-day triple therapy against Helicobacter pylori. J Gastrointestin Liver Dis. <em>25<\/em>, 283-288.","DOI":"10.15403\/jgld.2014.1121.253.7hp"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S136240"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1138"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.007"},{"key":"ref68","unstructured":"UMIN-CRT Clinical Trial (). Comparison of dual amoxicillin\/vonoprazan therapy and triple vonoprazan\/amoxicillin\/clarithromycin or metronidazole therapy for H. pylori eradication.Available from URL: <a href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000026374\" target=\"_blank\">https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000026374<\/a>"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.16-86"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0374-x"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16654499"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312028"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13462"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.02.021"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2002.00105.x"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4439-0"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70142-8"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34218"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i39.6523"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2016.1192551"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1227-8"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1207-z"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Shan, J, Oshima, T, and Muto, T (2015). Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis. J Gas-troenterol. <em>50<\/em>, 414-423.","DOI":"10.1007\/s00535-014-0988-1"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.7.649"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.45"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.19"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1209-2"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13461"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1159\/000456072"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17705329"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13876"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1166-4"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-10-787"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91843-0"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0171-6"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12050"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12100"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.3310\/hta10380"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05133.x"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90253-7"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.010"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0455-2"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314010"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0541-z"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-54"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314852"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1560-3"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.11.031"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313312"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1371-9"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1369-3"},{"key":"ref116","unstructured":"(). Vonoprazan study in patients with erosive esophagitis to evaluate long-term safety.Available from URL: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02679508\" target=\"_blank\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02679508<\/a>"}],"updated-by":[{"DOI":"10.5056\/jnm18029a","type":"addendum","label":"Addendum","source":"publisher","updated":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000}}],"container-title":["Journal of Neurogastroenterology and Motility"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/JNM2\/2018\/024\/JNM024-03-03.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T14:28:39Z","timestamp":1604240919000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jnmjournal.org\/journal\/view.html?doi=10.5056\/jnm18029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,7,30]]}},"alternative-id":["10.5056\/jnm18029"],"URL":"https:\/\/doi.org\/10.5056\/jnm18029","relation":{},"ISSN":["2093-0879","2093-0887"],"issn-type":[{"value":"2093-0879","type":"print"},{"value":"2093-0887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]},"assertion":[{"value":"http:\/\/www.jnmjournal.org\/journal\/view.html?doi=10.5056\/jnm18029","URL":"http:\/\/www.jnmjournal.org\/journal\/view.html?doi=10.5056\/jnm18029","name":"the_journal","label":"J Neurogastroenterol Motil","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2018-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2018 The Korean Society of Neurogastroenterology and Motility","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}