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Maintenance strategies in stage IV non-small-cell lung cancer (NSCLC): in which patients, with which drugs? Ann Oncol 2013 Dec 18 [Epub].","DOI":"10.1093\/annonc\/mdt529"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Lee DY, Park JS, Leem CY, et al. The outcomes of oncothermia with chemotherapy for far advanced lung cancer (3 cases of adenocarcinoma). Proceedings of the 32nd Conference of the International Clinical Hyperthermia Society; 2013 Nov 8-10; Guangzhou, China. [place unknown]: International Clinical Hyperthermia Society; 2013.","DOI":"10.1155\/2013\/690739"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Lee Y. Oncothermia application for various malignant diseases. Conference Papers in Medicine: vol. 2013. Cairo:Hindawi Publishing Co.; 2013.","DOI":"10.1155\/2013\/245156"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Kim JH, Kim DR. 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