{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:47:20Z","timestamp":1785750440317,"version":"3.56.0"},"reference-count":21,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphopenia and lymphocytic metabolism have been individually associated with poor prognosis in sepsis; however, the\u00a0relationship between these factors remains poorly understood. We evaluated whether lymphocyte count and lymphocytic mitochondrial metabolism are associated with the\u00a0development of\u00a0persistent inflammation, immunosuppression, and catabolic syndrome (PICS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A\u00a0prospective cohort study was conducted in four clinical-surgical intensive care units (ICUs). We included critically ill patients with sepsis requiring vasopressor support and assessed mitochondrial metabolism in isolated lymphocytes, including Complex I- and II-linked respiration, at sepsis diagnosis (day 1) and on day 3. Absolute lymphocyte counts and derived ratios, e.g., neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were evaluated at the\u00a0same time points. The\u00a0primary outcome was the\u00a0association between mitochondrial respiratory function and PICS. Secondary outcomes included associations between lymphocyte counts, derived biomarkers, and mitochondrial respiration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 64 patients, 10 of\u00a0whom developed PICS. At sepsis diagnosis, patients who did not develop PICS exhibited significantly higher Complex I\u00a0and \nII-linked respiration compared with those who did (mean difference [MD] for Complex I: \n115 pmol O\u2082 s\u20131 10\u20136 cells; 95% CI: 13\u2013291; P = 0.01; MD for Complex II: 171 pmol O\u2082 s\u20131 10\u20136 cells; 95% CI: 31\u2013397; P = 0.01). No significant differences were observed in the\u00a0delta (day 3 minus day 1) mitochondrial respiration or lymphocyte count between the\u00a0PICS and non-PICS groups. Additionally, lymphocyte counts and derived ratios showed no significant correlation with Complex I\u00a0or II respiration, even when stratified by quartiles across time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that reduced mitochondrial Complex I- and II-linked respiration in lymphocytes at sepsis onset may be associated with the\u00a0development of PICS. Nevertheless, this association remains exploratory and requires confirmation in larger, adequately powered studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5114\/ait\/222713","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:26:59Z","timestamp":1785749219000},"page":"164-171","source":"Crossref","is-referenced-by-count":0,"title":["Persistent inflammation, immunosuppression, and catabolism are associated with impaired lymphocytic mitochondrial metabolism during the early phase of sepsis. A single-center, prospective cohort study"],"prefix":"10.5114","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-4256","authenticated-orcid":true,"given":"Wagner","family":"Nedel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso","family":"Kopczynski de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo S.","family":"Rodolphi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria","family":"Girelli de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Valdameri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Soares Herasinczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"Pinko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-8466","authenticated-orcid":false,"given":"Luis Valmor","family":"Portela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref-1954520","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref-1954521","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3398"},{"key":"ref-1954522","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-021-00423-6"},{"key":"ref-1954523","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318256e000"},{"key":"ref-1954524","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01038-0"},{"key":"ref-1954525","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001675"},{"key":"ref-1954526","doi-asserted-by":"crossref","unstructured":"Jing J, Wei Y, Dong X, Li D, Zhang C, Fang Z, et al. Characteristics and clinical prognosis of septic patients with persistent lymphopenia. J Intensive Care Med 2024; 39: 733-741. 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