{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:08:25Z","timestamp":1773281305000,"version":"3.50.1"},"reference-count":16,"publisher":"Termedia Sp. z.o.o.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"Introduction<\/jats:title>A high-flow nasal cannula (HFNC) is an alternative device for oxygena\u00adtion, which improves gas exchange and reduces the work of breathing. Postextubation respiratory failure causes increased morbidity and mortality. HFNC has been widely employed during the COVID-19 pandemic. The purpose of this paper is to report a single-centre experience on the effectiveness and safety of HFNC in weaning COVID-19 patients.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Nine patients showed severe acute respiratory failure and interstitial pneumonia due to SARS-CoV-2. After mechanical ventilation (5 Helmet CPAP, 4 invasive mechanical ventilation), they were de-escalated to HFNC. Settings were: 34\u201337\u00b0C, flow from 50 to 60 L min-1. FiO2 was set to achieve appropriate SpO2.<\/jats:p><\/jats:sec>Results<\/jats:title>Nine patients (4 females; age 63 \u00b1 13.27 years; BMI 27.2 \u00b1 4.27) showed a baseline PaO2\/FiO2 of 109 \u00b1 45 mm Hg. After a long course of ventilation all patients improved (PaO2\/FiO2 336 \u00b1 72 mm Hg). Immediately after initiation of HFNC (2 hours), PaO2\/FiO2 was 254 \u00b1 69.3 mm Hg. Mean ROX index at two hours was 11.17 (range: 7.38\u201314.4). It was consistent with low risk of HFNC failure. No difference was observed on lactate. After 48 hours of HFNC oxygen therapy (day 3), mean PaO2\/FiO2 increased to 396 \u00b1 83.5 mm Hg. All patients recovered from respiratory failure after 7 \u00b1 4.1 days.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HFNC might be helpful in weaning COVID-19 respiratory failure. Effectiveness and comfort should be assessed between 2 and 48 hours. Clinical outcomes, oxygenation, and ROX index should be considered, to rule out the need for intubation. Further evidence is required for firm conclusions.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2020.101007","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:29:28Z","timestamp":1609792168000},"page":"373-376","source":"Crossref","is-referenced-by-count":9,"title":["Clinical outcomes of high-flow nasal cannula in COVID-19 associated postextubation respiratory failure. 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