{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:27:19Z","timestamp":1782584839944,"version":"3.54.5"},"reference-count":39,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Shivering is a common complication of neuraxial anaesthesia. We compared the efficacy of tramadol, clonidine and pregabalin in preventing post-spinal anaes\u00adthesia shivering in hysteroscopic procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized, triple-blind, controlled clinical trial involving 120 ASA I\u2013II women, aged 18\u201360 years. The patients were randomly allocated to receive either oral clonidine 0.2 mg (group C), tramadol 100 mg (group T), pregabalin 150 mg (group P) or &lt;i&gt;&lt;i&gt;&lt;i&gt;placebo&lt;\/i&gt;&lt;\/i&gt;&lt;\/i&gt; (group O) 90 minutes before spinal anaesthesia. The body tempe\u00adrature was monitored at the forehead and tympanic membrane. The primary outcome was the occurrence of perioperative shivering. The secondary outcomes were the side effects and meperidine requirements to treat shivering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups had comparable demographic data. Group C showed the lowest incidence, severity and number of intraoperative and postoperative shivering attacks. The time to the first shivering attack was significantly longer in group C than the other groups and in group T than groups P and O. The severity of shivering attacks was comparable among groups C, T and P while being significantly lower than group O. Meperidine requirements were significantly lower in group C. Groups C, T and P had a significantly higher sedation score than group O. The incidences of dizziness, nausea and vomiting were highest in group T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tramadol, pregabalin and clonidine seem to be effective oral premedications to reduce the incidence, frequency and severity of post-spinal shivering but clonidine proved to be more effective and tolerable.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2020.97579","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:47:27Z","timestamp":1598428047000},"page":"187-196","source":"Crossref","is-referenced-by-count":7,"title":["Effects of oral premedication with tramadol, pregabalin or clonidine on shivering after spinal anaesthesia in patients undergoing hysteroscopic procedures"],"prefix":"10.5114","volume":"52","author":[{"given":"Khaled Mohamed","family":"Gaballah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabry Ibrahim","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref-1381254","doi-asserted-by":"publisher","DOI":"10.1016\/j.rapm.2007.11.006"},{"key":"ref-1381255","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000700011"},{"key":"ref-1381256","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199511000-00008"},{"key":"ref-1381257","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012605"},{"key":"ref-1381258","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0102900209"},{"key":"ref-1381259","doi-asserted-by":"publisher","DOI":"10.21454\/rjaic.7518.251.xum"},{"key":"ref-1381260","first-page":"76","article-title":"Comparing the effects of clonidine and pregabalin on postoperative shivering and pain in patients undergoing laparoscopic cholecystectomy","volume":"8","author":"Hashemian M","year":"2017","unstructured":"Hashemian M, Jourian J, Lashkarizadeh MR. Comparing the effects of clonidine and pregabalin on postoperative shivering and pain in patients undergoing laparoscopic cholecystectomy. Pharmacophore 2017; 8: 76-81.","journal-title":"Pharmacophore"},{"key":"ref-1381261","first-page":"22","volume-title":"Anesthesiology","author":"Grocott HP.","year":"2018","unstructured":"Grocott HP. Thermoregulation and perioperative hypothermia. In: Longnecker DE, Mackey MF, Sandberg WS, et al. (eds.) Anesthesiology. Third Edition. McGrwaw Hill Education, USA 2018, 1414: 22.","edition":"Third Edition"},{"key":"ref-1381262","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1404200405"},{"key":"ref-1381263","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1997.006-az006.x"},{"key":"ref-1381264","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/0140-6736(91)91895-2","article-title":"Perioperative shivering","volume":"338","author":"Crossley AW","year":"1991","unstructured":"Crossley AW, Mcvey FK, Cartwright DP. 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