{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:19:55Z","timestamp":1791569995101,"version":"4.3.4"},"reference-count":12,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"Background<\/jats:title>Ketamine has bronchodilation properties. The aim of the single-centre, evaluator-blinded, randomised clinical trial study was to evaluate whether continuous infusion of ketamine is associated with improvement in respiratory mechanics correlated with bronchospasm relief, as compared with continuous infusion of fentanyl.<\/jats:p><\/jats:sec>Methods<\/jats:title>Adult patients submitted to invasive mechanical ventilation were included if they had an acute severe bronchospasm, due to status asthmaticus or COPD exacerbation. They were randomised to ketamine or a standard IV analgesia with fentanyl, both in bolus and continuous infusion. Measurements of respiratory mechanics (airway resistance \u2013 R<sub>smax<\/sub>, dynamic compliance \u2013 C<sub>dyn<\/sub> and intrinsic PEEP \u2013 PEEPi) both at baseline and 3 and 24 h after randomisation were performed. The main outcome of this study was to evaluate the improvement of R<sub>smax<\/sub> in 3 h of continuous infusion of the study drugs.<\/jats:p><\/jats:sec>Results<\/jats:title>Ketamine use was not associated with greater reduction in R<sub>smax<\/sub> when compared with fentanyl, either after 3 h (0 cm H<sub>2<\/sub>O L\u20131 s\u20131 \u00b1 6 vs. \u20133 cm H<sub>2<\/sub>O L\u20131 s\u20131 \u00b1 7.7, respectively; P = 0.16) or after 24 h (\u20133 cm H<sub>2<\/sub>O L\u20131 s\u20131 \u00b1 17 vs. \u20133.5 cm H<sub>2<\/sub>O L\u20131 s\u20131 \u00b1 13.7, respectively; P = 0.73). Patients randomized to the ketamine group did not have better improvements in delta PEEPi as compared with fentanyl in 3 h (P = 0.77) or in 24 h (P = 0.72).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this study, ketamine use was not associated with improvement in ventilatory variables associated with bronchospasm.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2020.97765","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:47:27Z","timestamp":1598428047000},"page":"215-218","source":"Crossref","is-referenced-by-count":18,"title":["Negative results for ketamine use in severe acute bronchospasm: a randomised controlled trial"],"prefix":"10.5114","volume":"52","author":[{"given":"Wagner L.","family":"Nedel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael L.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz G.","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiani","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo da S.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref-1381350","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328348bf09"},{"key":"ref-1381351","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S168983"},{"key":"ref-1381352","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2010.11.004"},{"key":"ref-1381353","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.5430"},{"key":"ref-1381354","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.117048"},{"key":"ref-1381355","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009337941"},{"key":"ref-1381356","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70319-0"},{"key":"ref-1381357","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.1.90"},{"key":"ref-1381358","volume-title":"Measurements of Respiratory Mechanics During Machanical Ventilation","author":"Iotti GA","year":"1999","unstructured":"Iotti GA, Braschi A. Measurements of Respiratory Mechanics During Machanical Ventilation. Hamilton Medical Scientific Library, Rhazuns 1999."},{"key":"ref-1381359","first-page":"812","article-title":"Continuous intravenous infusion of ketamine for maintenance sedation","volume":"77","author":"Miller AC","year":"2011","unstructured":"Miller AC, Jamin CT, Elamin EM. Continuous intravenous infusion of ketamine for maintenance sedation. Minerva Anestesiol 2011; 77: 812-820.","journal-title":"Minerva Anestesiol"},{"key":"ref-1381360","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206740"},{"key":"ref-1381361","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00404903"}],"container-title":["Anaesthesiology Intensive Therapy"],"original-title":[],"link":[{"URL":"https:\/\/www.ait-journal.com\/pdf-120174-121947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ait-journal.com\/pdf-120174-121947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T11:00:06Z","timestamp":1743073206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ait-journal.com\/Negative-results-for-ketamine-use-in-severe-acute-bronchospasm-a-randomised-controlled,120174,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"alternative-id":["120174"],"URL":"https:\/\/doi.org\/10.5114\/ait.2020.97765","relation":{},"ISSN":["1642-5758","1731-2531"],"issn-type":[{"value":"1642-5758","type":"print"},{"value":"1731-2531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}