{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:58:06Z","timestamp":1760785086194,"version":"3.40.3"},"reference-count":22,"publisher":"Termedia Sp. z.o.o.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the predictive value of mid-regional pro-adrenomedullin (MR-proADM) compared to routine clinical and laboratory parameters in patients with COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 135 adult patients hospitalized with COVID-19 were included in a prospective single-centre study. In addition to routine parameters, the levels of MR-proADM in blood plasma were measured on the day of hospitalization. The patients were divided into 2 groups: those who survived and were discharged (n = 115, 85%) and those who did not survive (n = 20, 15%). Data are presented as median and interquartile range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The non-survivors had a statistically significantly greater age (73.4 [63.5\u201384.8] vs. 62.2 [50.3\u201371.4] years, P = 0.001), a lower level of haemoglobin oxygen saturation (91 [87\u201392] vs. 92 [92\u201393]%, P &lt; 0.001), lower lymphocyte level (13 [7\u201330] vs. 21 [15\u201327]%, P = 0.03), higher lactate dehydrogenase (338 [273\u2013480] vs. 280 [233\u2013383] EU L\u20131, P = 0.04) and aspartate aminotransferase levels (49 [28\u201372] vs. 33 [23\u201347] EU L\u20131, P = 0.03), a higher National Early Warning (NEWS) score (7 [7\u2013 8] vs. 6 [5\u20137] points, P &lt; 0.001), and higher procalcitonin (0.16 [0.11\u20130.32] vs. 0.1 [0.07\u20130.18] ng mL\u20131, P = 0.006) and MR-proADM levels (1.288 [0.886\u20131.847] vs. 0.769 [0.6\u20130.955] nmol L\u20131, P &lt; 0.001). MR-proADM had the highest predictive value for death during hospital stay (cut-off: 0.895 nmol L\u20131, AUC ROC 0.78 [95% CI: 0.66\u20130.90], sensitivity 75%, specificity 69%, OR 6.58 [95% CI: 2.22\u201319.51]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with other indicators, MR-proADM has the highest predictive value for in-hospital mortality in patients with COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2022.115367","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T13:41:56Z","timestamp":1662126116000},"page":"242-246","source":"Crossref","is-referenced-by-count":6,"title":["Mid-regional pro-adrenomedullin as a\u00a0predictor of in-hospital mortality in adult patients with COVID-19: a\u00a0single-centre prospective study"],"prefix":"10.5114","volume":"54","author":[{"given":"Dmitry","family":"Popov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulyana","family":"Borovkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Rybka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Ramnyonok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Golukhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref-1376501","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"ref-1376502","unstructured":"Coronavirus disease (COVID-19) pandemic. Available at: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019 (Accessed: 29.08.2022).","article-title":"Coronavirus disease (COVID-19) pandemic"},{"key":"ref-1376503","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20082004"},{"key":"ref-1376504","doi-asserted-by":"publisher","DOI":"10.1186\/cc11447"},{"key":"ref-1376505","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.022"},{"key":"ref-1376506","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0561-y"},{"key":"ref-1376507","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0645"},{"key":"ref-1376508","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081171"},{"key":"ref-1376509","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051110"},{"key":"ref-1376510","doi-asserted-by":"publisher","DOI":"10.1080\/10623320701678326"},{"key":"ref-1376511","doi-asserted-by":"publisher","DOI":"10.1186\/cc9055"},{"key":"ref-1376512","article-title":"Report of a working party","author":"National Early Warning Score (NEWS): Standardising the assessment of acute-illness severity in the NHS","year":"2012","unstructured":"National Early Warning Score (NEWS): Standardising the assessment of acute-illness severity in the NHS. Report of a working party. Royal College of Physicians. London: RCP, 2012. [Electronic resource]. Available at: https:\/\/www.rcplondon.ac.uk\/file\/32\/download?token=5NwjEyTq (Accessed: 29.08.2022)."},{"key":"ref-1376513","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074111"},{"key":"ref-1376514","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00104412"},{"key":"ref-1376515","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00065212"},{"key":"ref-1376516","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024636"},{"key":"ref-1376517","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02856.x"},{"key":"ref-1376518","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2450"},{"key":"ref-1376519","doi-asserted-by":"publisher","DOI":"10.1186\/cc4892"},{"key":"ref-1376520","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.105312"},{"key":"ref-1376521","doi-asserted-by":"publisher","DOI":"10.1186\/cc4955"},{"key":"ref-1376522","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-112"}],"container-title":["Anaesthesiology Intensive Therapy"],"original-title":[],"link":[{"URL":"https:\/\/www.ait-journal.com\/pdf-144294-121783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ait-journal.com\/pdf-144294-121783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T10:38:07Z","timestamp":1743071887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ait-journal.com\/Mid-regional-pro-adrenomedullin-as-a-predictor-of-in-hospital-mortality-in-adult,144294,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["144294"],"URL":"https:\/\/doi.org\/10.5114\/ait.2022.115367","relation":{},"ISSN":["1642-5758","1731-2531"],"issn-type":[{"type":"print","value":"1642-5758"},{"type":"electronic","value":"1731-2531"}],"subject":[],"published":{"date-parts":[[2022,9,2]]}}}