{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:05:11Z","timestamp":1743134711258,"version":"3.40.3"},"reference-count":33,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vasopressors increase arterial pressure but they may have deleterious effects on mesenteric blood flow. We aimed to evaluate the response of gut biomarkers and superior mesenteric blood flow to different vasopressors with and without dobutamine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirty New Zealand rabbits were included and randomly allocated to 5 groups: group A\u00a0\u2013 sham group; group B \u2013 norepinephrine; group C \u2013 norepinephrine plus dobutamine; group D \u2013 vasopressin; and group E \u2013 vasopressin plus dobutamine. Mean arterial pressure (MAP) target was greater than 60 mmHg. Endotoxic shock was induced by intra\u00advenous injection of lipopolysaccharide (LPS) in four of the five groups. Aortic blood flow (Qao), superior mesenteric artery flow (QSMA) and lactate were measured after LPS injection. Enterocyte damage was evaluated by measurements of serum citrulline and intestinal fatty acid-binding protein (I-FABP) after 4 h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The largest reduction in Qao occurred in group D (64 \u00b1 17.3 to 38 \u00b1 7.5 mL min\u20131; P = 0.04). QSMA also declined significantly in groups D and E and remained lower than in the other groups over 4 h (group D \u2013 baseline: 65 \u00b1 31; 1 h: 37 \u00b1 10; 2 h: 38 \u00b1 10; 3 h: 46 \u00b1 26; and 4 h: 48 \u00b1 15 mL min\u20131; P &lt; 0.005; group E \u2013 baseline: 73 \u00b1 14; 1 h: 28 \u00b1 4.0; 2 h: 37 \u00b1 6.4; 3 h: 40 \u00b1 11; and 4 h: 48 \u00b1 11; P &lt; 0.005; all in mL min\u20131). Serum citrulline was significantly lower in groups D (P = 0.014) and E (P = 0.019) in comparison to group A. The fluid administration regimen was similar in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vasopressin seems to negatively impact gut enterocyte function during endotoxic shock despite the association of an inodilator and adequate fluid replacement.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2022.117264","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T06:32:15Z","timestamp":1657089135000},"page":"141-149","source":"Crossref","is-referenced-by-count":0,"title":["The effects of vasopressors with and without dobutamine on haemodynamics, metabolism and gut injury during endotoxic shock in rabbits. A\u00a0controlled study"],"prefix":"10.5114","volume":"54","author":[{"given":"Neymar E.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelma V.","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edgia M.","family":"Contrim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseli Aparecida Matheus","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loraine D.O.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Manoel","family":"Silva Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenno C.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Garcia Soriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzana M.","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref-1376957","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref-1376958","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"ref-1376959","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"ref-1376960","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"ref-1376961","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002255"},{"key":"ref-1376962","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000386"},{"key":"ref-1376963","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828c26b5"},{"key":"ref-1376964","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2831-1"},{"key":"ref-1376965","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e3180644e32"},{"key":"ref-1376966","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000283"},{"key":"ref-1376967","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199703000-00005"},{"key":"ref-1376968","first-page":"BR37","article-title":"Effects of dobutamine on gut mucosal nitric oxide production during endotoxic shock in rabbits","volume":"15","author":"Lobo SM","year":"2009","unstructured":"Lobo SM, Soriano FG, Barbeiro DF, et al. Effects of dobutamine on gut mucosal nitric oxide production during endotoxic shock in rabbits. Med Sci Monit 2009; 15: BR37-42.","journal-title":"Med Sci Monit"},{"key":"ref-1376969","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c88af1"},{"key":"ref-1376970","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710320"},{"key":"ref-1376971","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000267599.02140.86"},{"key":"ref-1376972","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1751-6"},{"key":"ref-1376973","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000215834.48023.57"},{"key":"ref-1376974","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00925.2002"},{"key":"ref-1376975","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200007000-00065"},{"key":"ref-1376976","doi-asserted-by":"publisher","DOI":"10.1186\/cc6197"},{"key":"ref-1376977","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.10.027"},{"key":"ref-1376978","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200205-447OC"},{"key":"ref-1376979","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0972CI"},{"key":"ref-1376980","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208943"},{"key":"ref-1376981","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000104201.62736.12"},{"key":"ref-1376982","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2256"},{"key":"ref-1376983","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.9705075"},{"key":"ref-1376984","article-title":"Aerobic Glycolysis","author":"Naifeh J","year":"2020","unstructured":"Naifeh J, Dimri M, Varacallo M. Biochemistry. Aerobic Glycolysis. StatPearls, Treasure Island (FL); 2020."},{"key":"ref-1376985","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0810-3"},{"key":"ref-1376986","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.12.005"},{"key":"ref-1376987","doi-asserted-by":"publisher","DOI":"10.5603\/AIT.a2017.0065"},{"key":"ref-1376988","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.10.002"},{"key":"ref-1376989","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000440"}],"container-title":["Anaesthesiology Intensive Therapy"],"original-title":[],"link":[{"URL":"https:\/\/www.ait-journal.com\/pdf-143153-121796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ait-journal.com\/pdf-143153-121796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T10:42:25Z","timestamp":1743072145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ait-journal.com\/The-effects-of-vasopressors-with-and-without-dobutamine-on-haemodynamics-metabolism,143153,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["143153"],"URL":"https:\/\/doi.org\/10.5114\/ait.2022.117264","relation":{},"ISSN":["1642-5758","1731-2531"],"issn-type":[{"type":"print","value":"1642-5758"},{"type":"electronic","value":"1731-2531"}],"subject":[],"published":{"date-parts":[[2022,7,4]]}}}