{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:29:29Z","timestamp":1760956169704,"version":"3.40.3"},"reference-count":18,"publisher":"Termedia Sp. z.o.o.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aortic stenosis (AS) is a cardiac valvular lesion that can cause sudden death. Spinal anesthesia (SA) has been considered a relative contraindication in patients with AS. We sought to compare outcomes in patients with AS undergoing SA versus general anesthesia (GA) for lower extremity total joint arthroplasty (TJA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective chart review was conducted of elective, primary TJA cases between January 1, 2011, and November 30, 2017, at three tertiary care academic medical centers. Participants included 89 patients with AS undergoing TJA with SA, and 74 with AS undergoing TJA with GA. Primary endpoints included 90-day mortality, blood transfusion, hospital length of stay (LOS), and the 90-day incidence of deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Propensity score matching was utilized to assess differences in outcomes between patients receiving GA vs. SA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After matching, there were no significant differences in mortality (GA 0% vs. SA 1%; OR: 1.01 [0.98, 1.05]; P = 0.498), serious complications GA 2.2% vs. SA 0%; OR: 1.00 [0.95, 1.05]; P = 0.233), blood transfusion (GA 12.4% vs. 9% SA; OR: 1.01 [0.86, 1.19]; P = 0.751) within 90 days in the GA vs. SA groups, nor hospital LOS (GA mean 3.0 vs. SA mean 2.9, \uf062 0.3 [\u20130.11, 0.70]; P = 0.153).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no differences in the incidence of mortality or serious complications in matched patients with AS undergoing elective primary lower extremity TJA under SA versus GA.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2022.117548","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T06:32:15Z","timestamp":1657089135000},"page":"108-113","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of mortality and serious complications in lower extremity total joint arthroplasty patients with aortic stenosis receiving spinal versus general anesthesia"],"prefix":"10.5114","volume":"54","author":[{"given":"Harold E.","family":"Chaves-Cardona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Ross","family":"Renew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron C.","family":"Spaulding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"ref-1376822","doi-asserted-by":"publisher","DOI":"10.2147\/RMHP.S34587"},{"key":"ref-1376823","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302265"},{"key":"ref-1376824","first-page":"1932","author":"Nussmeier NA","year":"2010","unstructured":"Nussmeier NA, Hauser M, Sarwar MF, Grigore AM, Searles BE. Anesthesia for cardiac surgical procedures. In: Miller\u2019s Anesthesia. Miller RD (ed.). 7th ed: Philadelphia: Elsevier\/Churchill Livingstone; 2010; 1932-1933.","edition":"7th ed"},{"key":"ref-1376825","doi-asserted-by":"publisher","DOI":"10.1016\/j.rapm.2004.06.010"},{"key":"ref-1376826","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000339"},{"key":"ref-1376827","first-page":"A5407","article-title":"Central regional anaesthesia in patients with aortic stenosis\u2013a systematic review","volume":"64","author":"Johansson S","year":"2017","unstructured":"Johansson S, Lind MN. Central regional anaesthesia in patients with aortic stenosis\u2013a systematic review. Dan Med J 2017; 64: A5407.","journal-title":"Dan Med J"},{"article-title":"Surgical Management of the Knee Evidence-Based Clinical Practice Guideline. Neuraxial Anesthesia 2015 [Moderate evidence supports that neuraxial anesthesia could be used in total knee arthroplasty (TKA) to improve select perioperative outcomes and complication rates compared to general anesthesia.]","author":"American Academy of Orthopaedic Surgeons","key":"ref-1376828","unstructured":"American Academy of Orthopaedic Surgeons. Surgical Management of the Knee Evidence-Based Clinical Practice Guideline. Neuraxial Anesthesia 2015 [Moderate evidence supports that neuraxial anesthesia could be used in total knee arthroplasty (TKA) to improve select perioperative outcomes and complication rates compared to general anesthesia.]. Available from: https:\/\/www.orthoguidelines.org\/guideline-detail?id=1300&tab=all_guidelines (Accessed: 14.02.2022)."},{"key":"ref-1376829","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.018"},{"key":"ref-1376830","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13480"},{"key":"ref-1376831","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12182"},{"key":"ref-1376832","first-page":"69","article-title":"Reducing bias in cancer research: application of propensity score matching","volume":"29","author":"Reeve BB","year":"2008","unstructured":"Reeve BB, Smith AW, Arora NK, Hays RD. Reducing bias in cancer research: application of propensity score matching. Health Care Financ Rev 2008; 29: 69-80.","journal-title":"Health Care Financ Rev"},{"key":"ref-1376833","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1467-6419.2007.00527.x","article-title":"Some practical guidance for the implementation of propensity score matching","volume":"22","author":"Caliendo M","year":"2008","unstructured":"Caliendo M, Kopeinig S. Some practical guidance for the implementation of propensity score matching. Journal of Economic Surveys 2008; 22: 31-72.","journal-title":"Journal of Economic Surveys"},{"key":"ref-1376834","doi-asserted-by":"publisher","DOI":"10.1016\/j.rapm.2007.09.008"},{"key":"ref-1376835","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0026"},{"key":"ref-1376836","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2006.01.007"},{"key":"ref-1376837","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2014.67.2.129"},{"key":"ref-1376838","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2013.03.010"},{"key":"ref-1376839","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2113514"}],"container-title":["Anaesthesiology Intensive Therapy"],"original-title":[],"link":[{"URL":"https:\/\/www.ait-journal.com\/pdf-148143-121791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ait-journal.com\/pdf-148143-121791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T10:40:18Z","timestamp":1743072018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ait-journal.com\/Comparison-of-mortality-and-serious-complications-in-lower-extremity-total-joint,148143,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["148143"],"URL":"https:\/\/doi.org\/10.5114\/ait.2022.117548","relation":{},"ISSN":["1642-5758","1731-2531"],"issn-type":[{"type":"print","value":"1642-5758"},{"type":"electronic","value":"1731-2531"}],"subject":[],"published":{"date-parts":[[2022,7,5]]}}}