{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:14:28Z","timestamp":1780085668629,"version":"3.54.0"},"reference-count":39,"publisher":"Termedia Sp. z.o.o.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesthesiol Intensive Ther"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>COVID-19 is associated with severe respiratory distress and high mortality. We investigated the evolution of the respiratory mechanics in COVID-19 acute respiratory distress syndrome (ARDS) and the occurrence of a restrictive respiratory pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>A retrospective, single-centre study including patients admitted to the ICU during the first wave of the pandemic (March-April 2020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 141 consecutive patients were included. Many patients developed a restrictive pattern of respiratory mechanics during the course of the disease. Fifty-two patients died in the hospital (36.8%). In 29 cases (58% of the deceased) death was associated with a pattern of pulmonary mechanics, indicating a restrictive evolution of ARDS. Other diagnoses related to death were pulmonary embolism (n = 7, 14%), septic shock (n = 17, 33%), and other causes (n = 10, 20%), with some patients combining at least 2 of these diagnoses. In a multivariate analysis, age (OR = 1.06; 95% CI: 1.01\u20131.12; P = 0.029) and the administration of steroid pulses (OR = 2.7; 95% CI: 1.1\u20136.8; P = 0.03) were associated with the development of a restrictive pulmonary pattern and a higher level of plasmatic interleukin-6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COVID-19 ARDS is associated with high mortality associated with a specific pattern of respiratory mechanics and sustained activation of innate immunological response. Age and administration of high-dose steroid pulses are associated with this clinical picture.<\/jats:p><\/jats:sec>","DOI":"10.5114\/ait.2022.121091","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T11:02:22Z","timestamp":1668682942000},"page":"295-301","source":"Crossref","is-referenced-by-count":6,"title":["Respiratory mechanics in late COVID-19 ARDS \u2013 a\u00a0restrictive pattern is strongly associated with death. 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