{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:27:16Z","timestamp":1792200436721,"version":"4.4.0"},"reference-count":21,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiac amyloidosis (CA) is a restrictive cardiomyopathy characterized by amylin deposits in the heart muscle. While the prevalence of atrial arrhythmias in CA is high, the data regarding the outcomes of catheter ablation in these patients are limited. This study aimed to elucidate the safety and efficacy of catheter ablation for treating atrial arrhythmias in patients with CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive literature search across PubMed, Embase and Cochrane from inception till January 2024 for randomized control trials and observational studies reporting catheter ablation (cryoablation or radiofrequency ablation) for the treatment of atrial arrhythmias (AAs) (atrial flutter, atrial fibrillation, atrial tachycardia) in patients with cardiac amyloidosis. The primary outcome of interest was pooled recurrence rate. The secondary outcomes were re-ablation rate and all-cause mortality. All data were analyzed using the Hedges-Olkin random-effects model and presented as percentage proportions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9 cohort studies (n = 283) were included. The median age ranged from 67.6 years to 76.5 years, with a median follow-up of 13 to 60 months. The pooled incidence of recurrence rate was 45% (95% CI = 23.4% to 66.5%). The pooled proportion of re-ablation rate was 20% (95% CI = 3.3% to 36.7%) and of all-cause mortality was 30.7% (95% CI = 15.5% to 46%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high rates of recurrence, need for re-ablation, and associated mortality highlight the need for better patient selection. Prospective and randomized controlled data are needed to further study the outcomes of catheter ablation in these patients.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad\/209031","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:54:18Z","timestamp":1758282858000},"page":"139-145","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of catheter ablation for atrial arrhythmias in patients with cardiac amyloidosis: a systematic review and meta-analysis"],"prefix":"10.5114","volume":"10","author":[{"given":"Jawad","family":"Basit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushood","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaofashan","family":"Zaheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman Ali","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Naveed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Chadi","family":"Alraies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref-1518432","doi-asserted-by":"crossref","unstructured":"Rambaran RN, Serpell LC. Amyloid fibrils: abnormal protein assembly. Prion 2008; 2: 112-7.","DOI":"10.4161\/pri.2.3.7488"},{"key":"ref-1518433","doi-asserted-by":"crossref","unstructured":"Halatchev IG, Zheng J, Ou J. Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), previously known as senile cardiac amyloidosis: clinical presentation, diagnosis, management and emerging therapies. J Thorac Dis 2018; 10: 2034-45.","DOI":"10.21037\/jtd.2018.03.134"},{"key":"ref-1518434","doi-asserted-by":"crossref","unstructured":"Lane T, Fontana M, Martinez-Naharro A, et al. Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis. 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Trends Cardiovasc Med 2018; 28: 10-21.","DOI":"10.1016\/j.tcm.2017.07.004"},{"key":"ref-1518439","doi-asserted-by":"crossref","unstructured":"Giancaterino S, Urey MA, Darden D, Hsu JC. Management of arrhythmias in cardiac amyloidosis. JACC Clin Electrophysiol 2020; 6: 351-61.","DOI":"10.1016\/j.jacep.2020.01.004"},{"key":"ref-1518440","doi-asserted-by":"crossref","unstructured":"Cappato R, Calkins H, Chen SA, et al. Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation. Circ Arrhythm Electrophysiol 2010; 3: 32-8.","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"ref-1518441","doi-asserted-by":"crossref","unstructured":"Yokoyama Y, Miyamoto K, Nakai M, et al. Complications associated with catheter ablation in patients with atrial fibrillation: a report from the JROAD-DPC study. J Am Heart Assoc 2021; 10: e019701.","DOI":"10.1161\/JAHA.120.019701"},{"key":"ref-1518442","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372: n71.","DOI":"10.1136\/bmj.n71"},{"key":"ref-1518443","doi-asserted-by":"crossref","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ 2016; 355: i4919.","DOI":"10.1136\/bmj.i4919"},{"key":"ref-1518444","doi-asserted-by":"crossref","unstructured":"Dale Z, Chandrashekar P, Al-Rashdan L, et al. Management strategies for atrial fibrillation and flutter in patients with transthyretin cardiac amyloidosis. Am J Cardiol 2021; 157: 107-14.","DOI":"10.1016\/j.amjcard.2021.07.028"},{"key":"ref-1518445","doi-asserted-by":"crossref","unstructured":"Sweat AO. Outcomes of radiofrequency catheter ablation of atrial arrhythmias in patients with cardiac amyloidosis. J Atrial Fibril Electrophysiol 2022; 15: 27-33.","DOI":"10.4022\/jafib.20200554"},{"key":"ref-1518446","doi-asserted-by":"crossref","unstructured":"Donnellan E, Wazni O, Kanj M, et al. Atrial fibrillation ablation in patients with transthyretin cardiac amyloidosis. Europace 2020; 22: 259-64.","DOI":"10.1093\/europace\/euz314"},{"key":"ref-1518447","doi-asserted-by":"crossref","unstructured":"Tan N, Mohsin Y, Hodge DO, et al. Catheter ablation for atrial arrhythmias in patients with cardiac amyloidosis. J Cardiovasc Electrophysiol 2016; 27: 1167-73.","DOI":"10.1111\/jce.13046"},{"key":"ref-1518448","doi-asserted-by":"crossref","unstructured":"Barrett C, Tumolo AZ, Tzou WS, et al. PO-651-06 Outcomes of atrial fibrillation ablation in patients with transthyretin cardiac amyloidosis. 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