{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:26:18Z","timestamp":1779924378742,"version":"3.53.1"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The present open-label, single-arm pilot study sought to evaluate the effects of a\u00a0nutraceutical combination containing fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Forty patients with mild-to-moderate hypercholesterolemia received the nutraceutical combination containing fermented red rice, liposomal berberine, and curcumin, once a\u00a0day for 8 weeks. The study outcomes included changes from baseline in lipid (total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-C), oxidized low-density lipoprotein (oxLDL), high-density-lipoprotein cholesterol (HDL-C), and triglycerides (TG)) and inflammatory parameters (high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-\uf061 (TNF-\uf061)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with baseline, the nutraceutical combination produced a\u00a0statistically significant reduction of TC (\u201320.4%, p &lt; 0.05), LDL-C (\u201327.6%, p &lt; 0.05), oxLDL (\u201323.2%, p &lt; 0.05), and TG (\u201317.9%, p &lt; 0.05). We also observed a\u00a0reduction from baseline for hs-CRP (\u201315.4%, p &lt; 0.05) and TNF-\uf061 (\u201314.3%, p &lt; 0.05). The treatment was well tolerated and none of the patients discontinued treatment due to adverse effects. No cases of myalgia or musculoskeletal system disorders were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nutraceutical combination of fermented red rice, liposomal berberine, and curcumin improves lipid profile and reduces markers of inflammation in low-risk dyslipidemic patients, with potential implications for primary prevention of cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad.2018.79597","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T10:14:36Z","timestamp":1547028876000},"page":"137-141","source":"Crossref","is-referenced-by-count":15,"title":["Effects of a nutraceutical combination of fermented \nred rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with \nmild-to-moderate hypercholesterolemia: an 8-week, open-label, single-arm pilot study"],"prefix":"10.5114","volume":"3","author":[{"given":"Marco","family":"Biagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Minoretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bertona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Emanuele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2018,11,14]]},"container-title":["Archives of Medical Science \u2013 Atherosclerotic Diseases"],"original-title":[],"link":[{"URL":"https:\/\/amsad.termedia.pl\/pdf-94177-71802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/amsad.termedia.pl\/pdf-94177-71802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:34:51Z","timestamp":1653554091000},"score":1,"resource":{"primary":{"URL":"https:\/\/amsad.termedia.pl\/Effects-of-a-nutraceutical-combination-of-fermented-r-nred-rice-liposomal-berberine,94177,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["94177"],"URL":"https:\/\/doi.org\/10.5114\/amsad.2018.79597","relation":{},"ISSN":["2451-0629"],"issn-type":[{"value":"2451-0629","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,14]]}}}