{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:45:37Z","timestamp":1778841937951,"version":"3.51.4"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>A\u00a0role for ficolin (FCN) 2 gene polymorphisms in the pathogenesis of recurrent severe streptococcal infections and rheumatic carditis has been suggested. The aim of the study was to evaluate a\u00a0possible relationship between single nucleotide polymorphisms located at positions -602 and -4 of the FCN2 gene and FCN2 serum levels and risk of development of rheumatic fever (RF) and rheumatic heart disease (RHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Seventy-seven Caucasian Egyptian patients with RF were recruited with a\u00a0control group of 43 healthy subjects. DNA was extracted for analysis of the FCN2 gene at positions -602 and -4 and serum protein level was measured by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FCN2 AA genotype at the -4 position was more frequently observed in RF and RHD patients, as compared to healthy subjects (p = 0.005 and p = 0.013, respectively); furthermore, the A\u00a0allele was identified as a\u00a0possible risk factor for the development of RF (p = 0.023, OR = 1.852, 95% CI: 1.085\u20133.159). The haplotype \u2013602\/\u20134 G\/A, which was associated with low median levels of L-ficolin, was observed more frequently in the RF group when compared to the healthy subjects (74\/162, 48.1% vs. 29\/420, 33.7%, OR = 1.834, 95% CI: 1\u00b7034\u20133.252, p = 0\u00b7038). Low serum ficolin 2 level was associated with ESV and EDV increases. FCN 2 level was significantly lower with AA genotypes than GG+AG genotypes of the -4 position (56.68 \u00b117.90 vs. 66.05 \u00b118.79, p = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polymorphisms linked to low levels of L-ficolin may render an individual at risk of recurrent and\/or severe streptococcal infection. The -4 AA genotype and -602\/-4 G\/A\u00a0haplotype are possible risk factors for the development of carditis.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad.2018.80999","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T10:14:36Z","timestamp":1547028876000},"page":"142-155","source":"Crossref","is-referenced-by-count":7,"title":["Association of ficolin-2 (FCN2) functional polymorphisms and protein levels with rheumatic fever and rheumatic heart disease: relationship with cardiac function"],"prefix":"10.5114","volume":"3","author":[{"given":"Manal F.","family":"Elshamaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa Abd","family":"El Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha","family":"Emam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A.","family":"Elghoroury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek M.","family":"Farid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Zakareya","family":"Zaher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solaf","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa Abd","family":"El-Aziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2018,12,15]]},"container-title":["Archives of Medical Science \u2013 Atherosclerotic Diseases"],"original-title":[],"link":[{"URL":"https:\/\/amsad.termedia.pl\/pdf-97319-71803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/amsad.termedia.pl\/pdf-97319-71803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:34:52Z","timestamp":1653554092000},"score":1,"resource":{"primary":{"URL":"https:\/\/amsad.termedia.pl\/Association-of-ficolin-2-FCN2-functional-polymorphisms-and-protein-levels-with-rheumatic,97319,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["97319"],"URL":"https:\/\/doi.org\/10.5114\/amsad.2018.80999","relation":{},"ISSN":["2451-0629"],"issn-type":[{"value":"2451-0629","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,15]]}}}