{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:20:39Z","timestamp":1790742039977,"version":"4.1.0"},"reference-count":46,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypertension is one of the most prevalent diseases in the world, accounting for millions of deaths each year. The reduction in the concentration of nitric oxide (NO) produced by the catalysis of endothelial nitric oxide synthase (eNOS) is associated with higher blood pressure (BP) levels. This reduction might be because of genetic polymorphisms. This study investigated the prevalence of the eNOS gene G894T polymorphism in women from northeast Brazil and its association with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This cross-sectional study included 810 women (aged 19\u201349 years). Sociodemographic, health, anthropometric, and BP data were collected. Hypertension was defined according to the following criteria: systolic BP \u2265 140 mm Hg, diastolic BP \u2265 90 mm Hg, the regular use of antihypertensive medication, or some combination thereof. Epithelial cells from the cheek mucosa were obtained for DNA extraction. Genotyping was performed via real-time PCR. The measure of association was the prevalence ratio (PR) and its 95% CI as calculated via Poisson regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of the GG, GT, and TT genotypes were 57.1%, 35.7%, and 7.2%, respectively. For each of these genotypes, the prevalence of hypertension in women was 17.9%, 23.6%, and 34.4%, respectively. Relative to the GG genotype, the PRs after adjusting for cofounding factors were 1.24 (95% CI: 0.95\u20131.61, p = 0.11) for GT and 1.76 (95% CI: 1.16\u20132.67, p &lt; 0.01) for TT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The T allele of the G894T polymorphisms is associated with hypertension in women. This may have implications for prevention and treatment.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad.2019.84539","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:25:39Z","timestamp":1557919539000},"page":"63-73","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of endothelial nitric oxide synthase (ENOS) gene G894T polymorphism and its association with hypertension: a\u00a0population-based study with Brazilian women"],"prefix":"10.5114","volume":"4","author":[{"given":"Abel Barbosa","family":"Lira Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrla C. O.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy B. 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Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension J Clin Hypertens (Greenwich). 16: 14-26.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref-618562","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/ng.3654","article-title":"Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension","volume":"48","author":"Surendran P","year":"2016","unstructured":"Surendran P, Drenos F, Young R, et al. (2016). 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Contribution of endothelial nitric oxide to blood pressure in humans Hypertension. 49: 170-7.","journal-title":"Hypertension"},{"key":"ref-618565","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1089\/ars.2009.2453","article-title":"The role of nitric oxide in myocardial repair and remodeling","volume":"11","author":"Otani H","year":"2009","unstructured":"Otani H. (2009). The role of nitric oxide in myocardial repair and remodeling Antioxid Redox Signal. 11: 1913-28.","journal-title":"Antioxid Redox Signal"},{"key":"ref-618566","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.285.16.2055","article-title":"Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension","volume":"285","author":"Thomas GD","year":"2001","unstructured":"Thomas GD, Zhang W, Victor RG. (2001). Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension JAMA. 285: 2055-7.","journal-title":"JAMA"},{"key":"ref-618567","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang PL","year":"1995","unstructured":"Huang PL, Huang Z, Mashimo H, et al. (1995). Hypertension in mice lacking the gene for endothelial nitric oxide synthase Nature. 377: 239-42.","journal-title":"Nature"},{"key":"ref-618568","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fphys.2013.00347","article-title":"Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium","volume":"4","author":"Qian J","year":"2013","unstructured":"Qian J, Fulton D. (2013). 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Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease Dis Markers. 31: 215-22.","journal-title":"Dis Markers"},{"key":"ref-618581","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10038-005-0270-8","article-title":"The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia","volume":"50","author":"Hillermann R","year":"2005","unstructured":"Hillermann R, Carelse K, Gebhardt GS. (2005). The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia J Hum Genet. 50: 415-9.","journal-title":"J Hum Genet"},{"key":"ref-618582","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjhyper.2004.02.013","article-title":"Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans","volume":"17","author":"Li R","year":"2004","unstructured":"Li R, Lyn D, Lapu-Bula R, et al. (2004). Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans Am J Hypertens. 17: 560-7.","journal-title":"Am J Hypertens"},{"key":"ref-618583","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/gtmb.2011.0342","article-title":"Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: comparison with myocardial infarction patients","volume":"16","author":"Gad MZ","year":"2012","unstructured":"Gad MZ, Abdel Rahman MF, Hashad IM, et al. (2012). 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Lack of evidence for contribution of Glu298Asp (G894T) polymorphism of endothelial nitric oxide synthase gene to plasma nitric oxide levels Thromb Res. 107: 129-34.","journal-title":"Thromb Res"},{"key":"ref-618585","first-page":"68","article-title":"Endothelial nitric oxide synthase (eNOS) Glu298-->Asp polymorphism (G894T) among south Indians","volume":"129","author":"Nishevitha NS","year":"2009","unstructured":"Nishevitha NS, Angeline T, Jeyaraj N. (2009). Endothelial nitric oxide synthase (eNOS) Glu298-->Asp polymorphism (G894T) among south Indians Indian J Med Res. 129: 68-71.","journal-title":"Indian J Med Res"},{"key":"ref-618586","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/ajh\/hps076","article-title":"Prevalence of hypertension among elderly persons in urban Brazil: a systematic review with meta-analysis","volume":"26","author":"Picon RV","year":"2013","unstructured":"Picon RV, Fuchs FD, Moreira LB, Fuchs SC. (2013). 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An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension PLoS One. 6: e24266.","journal-title":"PLoS One"},{"key":"ref-618591","doi-asserted-by":"crossref","first-page":"e113363","DOI":"10.1371\/journal.pone.0113363","article-title":"Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: an updated meta-analysis and systematic review","volume":"9","author":"Rai H","year":"2014","unstructured":"Rai H, Parveen F, Kumar S, Kapoor A, Sinha N. (2014). 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Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers Prev Med. 47: 167-71.","journal-title":"Prev Med"},{"key":"ref-618598","doi-asserted-by":"crossref","first-page":"H1472","DOI":"10.1152\/ajpheart.00520.2013","article-title":"Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats","volume":"306","author":"da Cunha","year":"2014","unstructured":"da Cunha NV, Pinge-Filho P, Panis C, et al. (2014). 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