{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T09:16:57Z","timestamp":1653556617898},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>No-re\ufb02ow is an infrequent but dreaded complication of percutaneous coronary intervention (PCI), where the culprit is obstruction of the downstream microvascular bed. The aim of this study was to evaluate the efficacy and safety of forceful injection of blood (autologous blood transfusion \u2013 ABT) in reversing no-reflow during PCI because data regarding its effectiveness is not available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>100\u2013120 ml of blood was withdrawn through guiding catheter over 3 to 5 min using a\u00a010 ml syringe and re-infused by forceful injection over 3 min through it, and its efficacy was assessed at 10 min using TIMI flow grade and quantitative corrected TIMI frame count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 93 patients received ABT following no-reflow. Their clinical presentation was ST-elevation myocardial infarction (STEMI) (n = 61; 65.6%), non-ST-elevation myocardial infarction (NSTEMI) (n = 23; 24.7%), and unstable angina (n = 9; 9.6%). It was observed among patients undergoing primary PCI (n = 18; 19.3%), pharmaco-invasive PCI (n = 27; 29%), rescue PCI (n = 11; 11.8%), and PCI for cardiogenic shock (n = 5; 5.3%). A\u00a0mean volume of 108 \u00b14 ml blood was transfused. Commonest culprit vessel was left anterior descending artery (n = 51; 54.8%) followed by right coronary (n = 29; 31.2%), left circumflex (n = 19; 10.8%), and saphenous vein grafts (n = 3; 3.2%). Following ABT, TIMI 3 flow was successfully restored in 77 (82.7%) patients. TIMI flow grade improved from 1.02 to 2.52 and cTIMI frame count decreased from 60.6 \u00b112 to 16.1 \u00b16 (p &lt; 0.001). ABT was well tolerated except transient hypotension (n = 17; 18.3%). Overall mortality was reported in 10 (10.7%) patients at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this largest and only study to date, ABT is a\u00a0safe and highly effective approach to reverse no-re\ufb02ow by raising driving pressure across the capillary bed.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad.2020.102424","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:32:21Z","timestamp":1609792341000},"page":"271-278","source":"Crossref","is-referenced-by-count":0,"title":["Non-pharmaco, non-invasive management of coronary no-reflow phenomenon"],"prefix":"10.5114","volume":"5","author":[{"given":"Santosh","family":"Sinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umeshwar","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awadesh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmodullah","family":"Razi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dibbendhu","family":"Khanra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3061","published-online":{"date-parts":[[2020,12,29]]},"container-title":["Archives of Medical Science \u2013 Atherosclerotic Diseases"],"original-title":[],"link":[{"URL":"https:\/\/amsad.termedia.pl\/pdf-127012-71889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/amsad.termedia.pl\/pdf-127012-71889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:48:21Z","timestamp":1653554901000},"score":1,"resource":{"primary":{"URL":"https:\/\/amsad.termedia.pl\/Non-pharmaco-non-invasive-management-of-coronary-no-reflow-phenomenon,127012,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["127012"],"URL":"https:\/\/doi.org\/10.5114\/amsad.2020.102424","relation":{},"ISSN":["2451-0629"],"issn-type":[{"value":"2451-0629","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,29]]}}}