{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:25:26Z","timestamp":1789410326964,"version":"build-2803163510"},"reference-count":0,"publisher":"Termedia Sp. z.o.o.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Med Sci Atheroscler Dis"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Insufficient inhibition of platelets in patients with atherosclerosis despite antiplatelet therapy leads to important clinical consequences. The present study evaluated the role of vitamin D (VD) deficiency in aspirin resistance (AR) in patients with stable coronary artery disease (CAD) treated with aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This study included 70 patients with stable CAD who had been using 100 mg aspirin for at least seven days. Serum 25-hydroxyvitamin D [25-(OH)D] concentration was measured and patients with 25-(OH)D level &lt; 20 ng\/dl were defined as the VD deficient group. A\u00a0Multiplate Platelet Function Analyzer (Multiplate) device was used to evaluate AR. Patients were defined as aspirin-sensitive (AS) when their AUC was \u2264 30 U, and aspirin resistant (AR) when their AUC was &gt; 30 U.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AUC was &gt; 30 U\u00a0in 15 (21%) patients and these patients were considered AR. The mean 25-(OH)D level was 18.7 \u00b112.2 ng\/ml in all patients. Forty-five (64%) patients were VD deficient. The rate of AR was higher in the VD deficient group than the sufficient group (29% vs. 8%, p = 0.041). The mean AUC was higher in the VD deficient group than the sufficient group (30.2 \u00b129.1 vs. 15.3 \u00b113.1 U; p = 0.018). In ROC analysis 25-(OH)D level &lt; 19.25 ng\/dl predicted AR with 86.7% sensitivity, 61.8% specificity (AUC = 0.696, 95% CI: 0.551\u20130.840, p = 0.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current study, an association was found between VD deficiency and AR in patients with stable CAD. VD supplementation may reduce platelet aggregation and overcome AR.<\/jats:p><\/jats:sec>","DOI":"10.5114\/amsad.2021.112242","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:35:45Z","timestamp":1653554145000},"page":"203-208","source":"Crossref","is-referenced-by-count":3,"title":["Association between Multiplate-measured aspirin resistance and vitamin D deficiency in stable coronary artery disease"],"prefix":"10.5114","volume":"6","author":[{"given":"Semih","family":"Surmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Karaca Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samim","family":"Emet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Ayduk Govdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Elitok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3061","published-online":{"date-parts":[[2021,12,29]]},"container-title":["Archives of Medical Science \u2013 Atherosclerotic Diseases"],"original-title":[],"link":[{"URL":"https:\/\/amsad.termedia.pl\/pdf-142996-71931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/amsad.termedia.pl\/pdf-142996-71931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:40:43Z","timestamp":1653554443000},"score":1,"resource":{"primary":{"URL":"https:\/\/amsad.termedia.pl\/Association-between-Multiplate-measured-aspirin-resistance-and-vitamin-D-deficiency,142996,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,29]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"alternative-id":["142996"],"URL":"https:\/\/doi.org\/10.5114\/amsad.2021.112242","relation":{},"ISSN":["2451-0629"],"issn-type":[{"value":"2451-0629","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,29]]}}}